Disease relevance of Gingival Hypertrophy

• Side effects included hypertension (40%), hypertrichosis (30%), gingival hypertrophy (10%), and a rise in the blood urea nitrogen level [1].
• It is important to distinguish idiopathic gingival fibromatosis from phenytoin-induced gingival hypertrophy [2].
• Vitamin C deficiency, or scurvy, produces follicular hyperkeratosis, perifollicular hemorrhages, gingival hypertrophy, and bleeding (1) [3].

High impact information on Gingival Hypertrophy

• Resolution of cyclosporin-induced gingival hypertrophy with metronidazole [4].
• Treatment of cyclosporine-induced gingival hypertrophy [5].
• METHODS: A review of all reports published since 1965 related to all forms of extramedullary leukemia (LC, GS, gingival hypertrophy, and meningeal leukemia [ML]) [6].
• A female child with a terminal deletion on the long arm of chromosome 14, 46,XX,del(14)(q31.1), presented with microcephaly, narrow palate, gingival hypertrophy, protuberant ears, and a small haemangioma on the back [7].
• A 20% transient elevation of serum creatinine occurred in one case, gingival hypertrophy in two and moderate hypertrichosis in two [8].

Chemical compound and disease context of Gingival Hypertrophy

• Of 9 patients receiving phenytoin (PHT) monotherapy, 3 (33.3%) had gingival hypertrophy; 15 of 18 (83.3%) patients receiving PHT in combination with phenobarbital (PB) manifested the disorder [9].
• Gingival hypertrophy is a well-documented side effect of cyclosporin therapy, but severe lip enlargement is less frequently recognised [10].
• Gingival hypertrophy regressed with the treatment of hydroxyurea [11].

Gene context of Gingival Hypertrophy

• Patients with gingival hypertrophy had higher mean endothelin concentrations than patients without this complication (4.0 pg ml(-1) versus 3.4 pg ml(-1), P<0.01), although CsA doses and concentrations were not different between these two groups [12].
• Gingival hypertrophy in acute megakaryoblastic leukemia [13].

References