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Disease relevance of Malnutrition


Psychiatry related information on Malnutrition

  • Although exposure to ethanol during a period comparable to the first two trimesters of human development with minimal or no undernutrition did not affect numerical density of synapses in visual cortex or caudate-putamen, synaptogenesis of caudate-putamen was altered in offspring of pair-fed animals [6].
  • However, a dose-dependent diminution in the ability of apomorphine to produce stereotyped behavior was noted in the malnourished group, suggesting that a class of brain dopamine receptors may be impaired or may have undergone homeostatic modification as a result of the undernutrition procedure [7].
  • Effect of prenatal undernutrition and phenobarbitone administration on discrimination learning and passive avoidance behaviour in rats [8].
  • Piracetam treatment improved the learning performance of normally reared rats and also attenuated the original and reversal learning deficits induced by prenatal undernutrition and postnatal impoverishment [9].
  • Circulating homocyst(e)ine can be increased by genetic deficiency of enzymatic pathways involved in its catabolism as well as by environmental factors including nutritional deficiencies, life style factors, physiological conditions, drugs and some diseases, which mainly induce deficiency of folate, vitamin B12 and vitamin B6 [10].

High impact information on Malnutrition


Chemical compound and disease context of Malnutrition


Biological context of Malnutrition


Anatomical context of Malnutrition


Gene context of Malnutrition

  • In contrast, placental Adipo-R2 mRNA is unchanged by undernutrition [31].
  • In addition, our data are consistent with the hypothesis that, by systemically increasing the levels of the proinflammatory cytokines IL-1 and IL-6, HF causes undernutrition and anemia [32].
  • At 8 days, no change was detected in the central IGF axis in response to undernutrition [33].
  • The neonatal serum 30 kDa complex (IGFBP-1 and -2) also increased in undernutrition and diabetes parallel to the expression of mRNA [34].
  • Thus, although the NPY system may not have a major role in the hyperphagia of freely fed lactating rats, it appears to have an important function in the response to undernutrition in such animals [35].

Analytical, diagnostic and therapeutic context of Malnutrition


  1. Nutritional status in the neuroendocrine control of growth hormone secretion: the model of anorexia nervosa. Scacchi, M., Ida Pincelli, A., Cavagnini, F. Frontiers in neuroendocrinology. (2003) [Pubmed]
  2. Increased energy expenditure in young children with cystic fibrosis. Shepherd, R.W., Holt, T.L., Vasques-Velasquez, L., Coward, W.A., Prentice, A., Lucas, A. Lancet (1988) [Pubmed]
  3. Ethanol abuse and heart disease. Regan, T.J., Haider, B. Circulation (1981) [Pubmed]
  4. Growth failure occurs through a decrease in insulin-like growth factor 1 which is independent of undernutrition in a rat model of colitis. Ballinger, A.B., Azooz, O., El-Haj, T., Poole, S., Farthing, M.J. Gut (2000) [Pubmed]
  5. Oxidative muscular injury and its relevance to hyperthyroidism. Asayama, K., Kato, K. Free Radic. Biol. Med. (1990) [Pubmed]
  6. Synaptic density of caudate-putamen and visual cortex following exposure to ethanol in utero. Lancaster, F., Delaney, C., Samorajski, T. Int. J. Dev. Neurosci. (1989) [Pubmed]
  7. A neuropharmacological analysis of central nervous system catecholamine systems in development protein malnutrition. Leahy, J.P., Stern, W.C., Resnick, O., Morgane, P.J. Developmental psychobiology. (1978) [Pubmed]
  8. Effect of prenatal undernutrition and phenobarbitone administration on discrimination learning and passive avoidance behaviour in rats. Jaiswal, A.K., Bhattacharya, S.K. Indian J. Exp. Biol. (1996) [Pubmed]
  9. Effect of piracetam, a nootropic agent, on discrimination learning deficits induced by parental undernutrition and environmental impoverishment in young rats. Jaiswal, A.K., Upadhyay, S.N., Bhattacharya, S.K. Indian J. Exp. Biol. (1989) [Pubmed]
  10. Hyperhomocyst(e)inemia: is this a novel risk factor in hypertension? Virdis, A., Ghiadoni, L., Salvetti, G., Versari, D., Taddei, S., Salvett, A. J. Nephrol. (2002) [Pubmed]
  11. Reduced mortality among children in southern India receiving a small weekly dose of vitamin A. Rahmathullah, L., Underwood, B.A., Thulasiraj, R.D., Milton, R.C., Ramaswamy, K., Rahmathullah, R., Babu, G. N. Engl. J. Med. (1990) [Pubmed]
  12. Brain cholecystokinin and nutritional status in rats and mice. Schneider, B.S., Monahan, J.W., Hirsch, J. J. Clin. Invest. (1979) [Pubmed]
  13. Liver triglyceride concentration and body protein metabolism in ethanol-treated rats: effect of energy and nutrient supplementation. Bernal, C.A., Vazquez, J.A., Adibi, S.A. Gastroenterology (1992) [Pubmed]
  14. Somatomedin-C levels in growth-impaired children and adolescents with chronic inflammatory bowel disease. Kirschner, B.S., Sutton, M.M. Gastroenterology (1986) [Pubmed]
  15. A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus. O'Neal, W.K., Hasty, P., McCray, P.B., Casey, B., Rivera-Pérez, J., Welsh, M.J., Beaudet, A.L., Bradley, A. Hum. Mol. Genet. (1993) [Pubmed]
  16. Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease. Austin, R.C., Lentz, S.R., Werstuck, G.H. Cell Death Differ. (2004) [Pubmed]
  17. Temporally-regulated retinoic acid depletion produces specific neural crest, ocular and nervous system defects. Dickman, E.D., Thaller, C., Smith, S.M. Development (1997) [Pubmed]
  18. Beta-cell secretory dysfunction in the pathogenesis of low birth weight-associated diabetes: a murine model. Jimenez-Chillaron, J.C., Hernandez-Valencia, M., Reamer, C., Fisher, S., Joszi, A., Hirshman, M., Oge, A., Walrond, S., Przybyla, R., Boozer, C., Goodyear, L.J., Patti, M.E. Diabetes (2005) [Pubmed]
  19. Chronic undernutrition accentuates insulin deficiency in rats with mild streptozocin-induced diabetes. Rao, R.H. Diabetes (1991) [Pubmed]
  20. Prospective hematologic evaluation of gastric exclusion surgery for morbid obesity. Amaral, J.F., Thompson, W.R., Caldwell, M.D., Martin, H.F., Randall, H.T. Ann. Surg. (1985) [Pubmed]
  21. In utero undernutrition reduces diabetes incidence in non-obese diabetic mice. Oge, A., Isganaitis, E., Jimenez-Chillaron, J., Reamer, C., Faucette, R., Barry, K., Przybyla, R., Patti, M.E. Diabetologia (2007) [Pubmed]
  22. Role of bradykinin B2 receptors in neonatal kidney growth. Yosipiv, I.V., Dipp, S., el-Dahr, S.S. J. Am. Soc. Nephrol. (1997) [Pubmed]
  23. Effects of estrogen and recombinant human insulin-like growth factor-I on ghrelin secretion in severe undernutrition. Grinspoon, S., Miller, K.K., Herzog, D.B., Grieco, K.A., Klibanski, A. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  24. Impaired regulation of glucose transporter 4 gene expression in insulin resistance associated with in utero undernutrition. Jaquet, D., Vidal, H., Hankard, R., Czernichow, P., Levy-Marchal, C. J. Clin. Endocrinol. Metab. (2001) [Pubmed]
  25. Effect of diphenylhydantoin on the bioavailability of citrus folate. Nelson, E.W., Cerda, J.J., Wilder, B.J., Streiff, R.R. Am. J. Clin. Nutr. (1978) [Pubmed]
  26. Etiology of anemia in pregnancy in south Malawi. van den Broek, N.R., Letsky, E.A. Am. J. Clin. Nutr. (2000) [Pubmed]
  27. Thymulin (facteur thymique serique) and zinc contents of the thymus glands of malnourished children. Jambon, B., Ziegler, O., Maire, B., Hutin, M.F., Parent, G., Fall, M., Burnel, D., Duheille, J. Am. J. Clin. Nutr. (1988) [Pubmed]
  28. Conditions associated with Alzheimer's disease at death: case-control study. Chandra, V., Bharucha, N.E., Schoenberg, B.S. Neurology (1986) [Pubmed]
  29. The fetal somatotropic axis during long term maternal undernutrition in sheep: evidence for nutritional regulation in utero. Bauer, M.K., Breier, B.H., Harding, J.E., Veldhuis, J.D., Gluckman, P.D. Endocrinology (1995) [Pubmed]
  30. Refeeding meal-fed rats increases lipoprotein lipase activity and deposition of dietary [14C]lipid in white adipose tissue and decreases oxidation to 14CO2. The role of undernutrition. Cruz, M.L., Williamson, D.H. Biochem. J. (1992) [Pubmed]
  31. Expression and regulation of adiponectin and receptor in human and rat placenta. Caminos, J.E., Nogueiras, R., Gallego, R., Bravo, S., Tovar, S., García-Caballero, T., Casanueva, F.F., Diéguez, C. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  32. Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines. Coutinho, H.M., McGarvey, S.T., Acosta, L.P., Manalo, D.L., Langdon, G.C., Leenstra, T., Kanzaria, H.K., Solomon, J., Wu, H., Olveda, R.M., Kurtis, J.D., Friedman, J.F. J. Infect. Dis. (2005) [Pubmed]
  33. Effects of early undernutrition on the brain insulin-like growth factor-I system. Chowen, J.A., Goya, L., Ramos, S., Busiguina, S., García-Segura, L.M., Argente, J., Pascual-Leone, A.M. J. Neuroendocrinol. (2002) [Pubmed]
  34. Effects of undernutrition and diabetes on serum and liver mRNA expression of IGFs and their binding proteins during rat development. Rivero, F., Goya, L., Aláez, C., Pascual-Leone, A.M. J. Endocrinol. (1995) [Pubmed]
  35. Neuropeptide Y receptor alterations in the hypothalamus of lactating rats. Pickavance, L.C., Widdowson, P.S., Vernon, R.G., Williams, G. Peptides (1999) [Pubmed]
  36. Organoselenium compounds as potential therapeutic and chemopreventive agents: a review. Soriano-Garcia, M. Current medicinal chemistry. (2004) [Pubmed]
  37. Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Roseboom, T.J., van der Meulen, J.H., Osmond, C., Barker, D.J., Ravelli, A.C., Bleker, O.P. Am. J. Clin. Nutr. (2000) [Pubmed]
  38. Glucocorticoids impair fetal beta-cell development in rats. Blondeau, B., Lesage, J., Czernichow, P., Dupouy, J.P., Bréant, B. Am. J. Physiol. Endocrinol. Metab. (2001) [Pubmed]
  39. Antihypertensive treatment in early postnatal life modulates prenatal dietary influences upon blood pressure in the rat. Sherman, R.C., Langley-Evans, S.C. Clin. Sci. (2000) [Pubmed]
  40. Direct right atrial catheterization for total parenteral nutrition. Oram-Smith, J.C., Mullen, J.L., Harken, A.H., Fitts, W.T. Surgery (1978) [Pubmed]
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