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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Ecchymosis

  • The patient, treated with heparin at a dosage of 25,000 units/day for 3 days and 12,500 units/day for an additional 4 days because of a clinically suspected deep venous thrombosis, developed (4 days after the discontinuation of heparin) a clinical and laboratory picture of severe DIC, manifested by subcutaneous hematomas and ecchymoses [1].
  • Examination revealed poorly fitting dentures, large confluent ecchymoses of both thighs, perifollicular hemorrhages, and a low serum ascorbic acid concentration [2].
  • When the results of the preoperative and postoperative steroid groups were compared, no significant difference was detected between the two groups in either edema or ecchymosis [3].
  • The development of cutaneous ecchymosis associated with a sudden fall in hemoglobin after the administration of alteplase should strongly suggest the possibility of diffuse subfascial hematoma [4].
  • Side effects occur frequently during a four-month tapering course of corticosteroids, including moon face, acne, infection, ecchymoses, hypertension, hirsutism, petechial bleeding and striae [5].

High impact information on Ecchymosis

  • The 30-day incidence of major bleeding complications was 6.5 percent in the enoxaparin group and 7.0 percent in the unfractionated-heparin group, but the incidence of bleeding overall was significantly higher in the enoxaparin group (18.4 percent vs. 14.2 percent, P=0.001), primarily because of ecchymoses at injection sites [6].
  • Although autopsy findings were generally nonspecific, multiple needle-puncture marks with surrounding ecchymoses are typical of IV cocaine abuse [7].
  • Spontaneous ecchymoses due to paroxetine administration [8].
  • CONCLUSION: Clinically significant local effects (eg, pain requiring parenteral analgesics, ecchymosis, swelling of over one half of the bitten extremity) occurred in one third of patients in our study [9].
  • Cystoscopy revealed severe mucosal ecchymoses with luminal hemorrhage and accumulations of crystalloid sludge [10].

Chemical compound and disease context of Ecchymosis


Biological context of Ecchymosis


Anatomical context of Ecchymosis


Gene context of Ecchymosis

  • On examination, amyloid deposition was found in the area of the lid ecchymoses, and corneal crystals were dispersed centrally and peripherally throughout all levels of the cornea on slit lamp examination [18].
  • We describe a case of primary amyloidosis (AL) with severe factor X (FX) deficiency in an amateur cyclist presenting with muscular pain at rest and ecchymoses in his legs [19].
  • However, in early October the same year, subcutaneous ecchymosis and intramuscular bleeding occurred for no apparent reason, and from the examination results his APTT was 106.4 s, factor VIII (FVIII) activity was <1%, and the anti-FVIII inhibitor titre was 6.9 BU ml(-1) [20].
  • Some ecchymosis appeared on the skin at the site of application of the cup in the initial stages, when the negative pressure exceeded the upper limits of -100 to -200 mbar [21].
  • The authors began to use 1-desamino-8-D-arginine vasopressin (DDAVP) Desmopressin Acetate routinely in their facelift patients who had a relatively high risk of bleeding, either from Von Willebrand factor deficiency, platelet dysfunction, aspirin intake, or ease of ecchymosis [22].

Analytical, diagnostic and therapeutic context of Ecchymosis


  1. An unusually prolonged case of heparin-induced thrombocytopenia and disseminated intravascular coagulation. Castaman, G., Ruggeri, M., Girardello, R., Rodeghiero, F. Haematologica (1992) [Pubmed]
  2. Scurvy: bilateral lower extremity ecchymoses and paraparesis. Allen, J.I., Naas, P.L., Perri, R.T. Annals of emergency medicine. (1982) [Pubmed]
  3. Effects of single-dose steroid usage on edema, ecchymosis, and intraoperative bleeding in rhinoplasty. Kara, C.O., Gökalan, I. Plast. Reconstr. Surg. (1999) [Pubmed]
  4. Massive subfascial hematoma after alteplase therapy for acute myocardial infarction. Khanlou, H., Malhotra, G., Khanlou, N., Eiger, G., Frechie, P. Am. J. Med. Sci. (1999) [Pubmed]
  5. Steroid-dependent Crohn's disease. Sandborn, W.J. Can. J. Gastroenterol. (2000) [Pubmed]
  6. A comparison of low-molecular-weight heparin with unfractionated heparin for unstable coronary artery disease. Efficacy and Safety of Subcutaneous Enoxaparin in Non-Q-Wave Coronary Events Study Group. Cohen, M., Demers, C., Gurfinkel, E.P., Turpie, A.G., Fromell, G.J., Goodman, S., Langer, A., Califf, R.M., Fox, K.A., Premmereur, J., Bigonzi, F. N. Engl. J. Med. (1997) [Pubmed]
  7. Death caused by recreational cocaine use. An update. Mittleman, R.E., Wetli, C.V. JAMA (1984) [Pubmed]
  8. Spontaneous ecchymoses due to paroxetine administration. Cooper, T.A., Valcour, V.G., Gibbons, R.B., O'Brien-Falls, K. Am. J. Med. (1998) [Pubmed]
  9. Copperhead snakebites: clinical severity of local effects. Scharman, E.J., Noffsinger, V.D. Annals of emergency medicine. (2001) [Pubmed]
  10. Encrusted cystitis secondary to Corynebacterium matruchotii infection in a horse. Saulez, M.N., Cebra, C.K., Heidel, J.R., Walker, R.D., Singh, R., Bird, K.E. J. Am. Vet. Med. Assoc. (2005) [Pubmed]
  11. Venlafaxine and ecchymosis. Kohn, S., Labbate, L.A. Canadian journal of psychiatry. Revue canadienne de psychiatrie. (1997) [Pubmed]
  12. Effects of three groin compression methods on patient discomfort, distress, and vascular complications following a percutaneous coronary intervention procedure. Chlan, L.L., Sabo, J., Savik, K. Nursing research. (2005) [Pubmed]
  13. Effect of ketorolac tromethamine (Toradol) on ecchymosis following anterior cruciate ligament reconstruction. Milne, J.C., Russell, J.A., Woods, G.W., Dalton, M.D. The American journal of knee surgery. (1995) [Pubmed]
  14. A comparative study of coumadin and aspirin for primary cardioembolic stroke and thromboembolic preventions of chronic rheumatic mitral stenosis with atrial fibrillation. Poungvarin, N., Opartkiattikul, N., Chaithiraphan, S., Viriyavejakul, A. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. (1994) [Pubmed]
  15. Clinical characteristics of children with snakebite poisoning and management of complications in the pediatric intensive care unit. Ozay, G., Bosnak, M., Ece, A., Davutoglu, M., Dikici, B., Gurkan, F., Bosnak, V., Haspolat, K. Pediatrics international : official journal of the Japan Pediatric Society. (2005) [Pubmed]
  16. Neonatal congenital Factor X deficiency. el Kalla, S., Menon, N.S. Pediatric hematology and oncology. (1991) [Pubmed]
  17. Complications of hypogastric artery cisplatin infusions. Menashe, D.S., Jacobs, S.C. Journal of surgical oncology. (1989) [Pubmed]
  18. Bilateral eyelid ecchymoses and corneal crystals: an unusual presentation of multiple myeloma. Goldstein, D.A., Schteingart, M.T., Birnbaum, A.D., Tessler, H.H. Cornea (2005) [Pubmed]
  19. Unusual bleeding manifestations in a case of primary amyloidosis with factor X deficiency but elevations of in vivo markers of thrombin formation and activity. Marcatti, M., Mauri, S., Tresoldi, M., Sabbadini, M.G., Vigano'D'Angelo, S., Safa, O., Rugarli, C., D'Angelo, A. Thromb. Res. (1995) [Pubmed]
  20. Successful steroid pulse treatment in childhood acquired haemophilia with nephrotic syndrome. Sakai, M., Shima, M., Shirahata, A. Haemophilia : the official journal of the World Federation of Hemophilia. (2005) [Pubmed]
  21. External tissue expansion successfully achieved using negative pressure. Lasheen, A.E., Salim, A., Hefny, M.R., Al-Bakly, E. Surgery today. (2004) [Pubmed]
  22. The use of DDAVP desmopressin reduces the incidence of microhematomas after facioplasty. Palaia, D.A., Rosenberg, M.H., Bonanno, P.C. Annals of plastic surgery. (2001) [Pubmed]
  23. Effect of steroids on edema, ecchymosis, and intraoperative bleeding in rhinoplasty. Kargi, E., Hoşnuter, M., Babucçu, O., Altunkaya, H., Altinyazar, C. Annals of plastic surgery. (2003) [Pubmed]
  24. Effects of different corticosteroids on edema and ecchymosis in open rhinoplasty. Gurlek, A., Fariz, A., Aydogan, H., Ersoz-Ozturk, A., Eren, A.T. Aesthetic plastic surgery. (2006) [Pubmed]
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