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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

FUT-175 inhibits the production of IL-6 and IL-8 in human monocytes.

We investigated the effect of FUT-175, a serine protease inhibitor, on the production of pro-inflammatory cytokines, interleukin-6 (IL-6) and interleukin-8 (IL-8), by monocytes stimulated with lipopolysaccharide (LPS). Monocytes isolated from healthy volunteers were incubated with LPS and various concentrations of FUT-175 for 12 hours. The productions of both IL-6 and IL-8, measured by enzyme-linked immunosorbent assay, were significantly inhibited by FUT at the concentration of 1 to 100 microg/ml in a dose-dependent manner. Furthermore, the expressions of IL-6 and IL-8 mRNAs were also inhibited by FUT-175. These data suggest that FUT-175 may reduce the pathological inflammatory conditions associated with enhanced production of proinflammatory cytokines including IL-6 and IL-8.[1]


  1. FUT-175 inhibits the production of IL-6 and IL-8 in human monocytes. Sugita, H., Ishiko, T., Ikei, S., Hirota, M., Ogawa, M. Res. Commun. Mol. Pathol. Pharmacol. (1999) [Pubmed]
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