The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SPINK13  -  serine peptidase inhibitor, Kazal type 13...

Homo sapiens

Synonyms: HBVDNAPTP1, HESPINTOR, Hepatitis B virus DNA polymerase transactivated serine protease inhibitor, Hespintor, LiESP6, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of SPINK5L3


Psychiatry related information on SPINK5L3


High impact information on SPINK5L3

  • Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome [8].
  • Most patients with idiopathic or hereditary CP, however, do not have mutations in PRSS1 (ref. 4). Here we analysed 96 unrelated children and adolescents with CP for mutations in the gene encoding the serine protease inhibitor, Kazal type 1 (SPINK1), a pancreatic trypsin inhibitor [1].
  • We have now screened complementary DNA libraries constructed from peripheral tissues to determine whether the messenger RNA encoding APP in these tissues is identical to that expressed in brain, and we identify a second APP mRNA that encodes an additional internal domain with a sequence characteristic of a Kunitz-type serine protease inhibitor [9].
  • Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules [10].
  • Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells [11].

Chemical compound and disease context of SPINK5L3


Biological context of SPINK5L3


Anatomical context of SPINK5L3


Associations of SPINK5L3 with chemical compounds


Physical interactions of SPINK5L3


Co-localisations of SPINK5L3


Regulatory relationships of SPINK5L3


Other interactions of SPINK5L3


Analytical, diagnostic and therapeutic context of SPINK5L3


  1. Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis. Witt, H., Luck, W., Hennies, H.C., Classen, M., Kage, A., Lass, U., Landt, O., Becker, M. Nat. Genet. (2000) [Pubmed]
  2. Inhibition of human immunodeficiency virus type 1 infectivity by secretory leukocyte protease inhibitor occurs prior to viral reverse transcription. McNeely, T.B., Shugars, D.C., Rosendahl, M., Tucker, C., Eisenberg, S.P., Wahl, S.M. Blood (1997) [Pubmed]
  3. Viral kinetics in patients with chronic hepatitis C treated with the serine protease inhibitor BILN 2061. Herrmann, E., Zeuzem, S., Sarrazin, C., Hinrichsen, H., Benhamou, Y., Manns, M.P., Reiser, M., Reesink, H., Calleja, J.L., Forns, X., Steinmann, G.G., Nehmiz, G. Antivir. Ther. (Lond.) (2006) [Pubmed]
  4. Bax mediates the apoptosis-sensitizing effect of maspin. Liu, J., Yin, S., Reddy, N., Spencer, C., Sheng, S. Cancer Res. (2004) [Pubmed]
  5. Immunochemical identification of the serine protease inhibitor alpha 1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease. Abraham, C.R., Selkoe, D.J., Potter, H. Cell (1988) [Pubmed]
  6. Host defense responses to infection by Mycobacterium tuberculosis. Induction of IRF-1 and a serine protease inhibitor. Qiao, Y., Prabhakar, S., Coccia, E.M., Weiden, M., Canova, A., Giacomini, E., Pine, R. J. Biol. Chem. (2002) [Pubmed]
  7. Alpha1 antichymotrypsin signal peptide polymorphism in sporadic Creutzfeldt-Jakob disease. Salvatore, M., Seeber, A.C., Nacmias, B., Petraroli, R., Sorbi, S., Pocchiari, M. Neurosci. Lett. (1997) [Pubmed]
  8. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Chavanas, S., Bodemer, C., Rochat, A., Hamel-Teillac, D., Ali, M., Irvine, A.D., Bonafé, J.L., Wilkinson, J., Taïeb, A., Barrandon, Y., Harper, J.I., de Prost, Y., Hovnanian, A. Nat. Genet. (2000) [Pubmed]
  9. Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease. Tanzi, R.E., McClatchey, A.I., Lamperti, E.D., Villa-Komaroff, L., Gusella, J.F., Neve, R.L. Nature (1988) [Pubmed]
  10. Serine protease inhibitor 6 protects cytotoxic T cells from self-inflicted injury by ensuring the integrity of cytotoxic granules. Zhang, M., Park, S.M., Wang, Y., Shah, R., Liu, N., Murmann, A.E., Wang, C.R., Peter, M.E., Ashton-Rickardt, P.G. Immunity (2006) [Pubmed]
  11. Expression of the serpin serine protease inhibitor 6 protects dendritic cells from cytotoxic T lymphocyte-induced apoptosis: differential modulation by T helper type 1 and type 2 cells. Medema, J.P., Schuurhuis, D.H., Rea, D., van Tongeren, J., de Jong, J., Bres, S.A., Laban, S., Toes, R.E., Toebes, M., Schumacher, T.N., Bladergroen, B.A., Ossendorp, F., Kummer, J.A., Melief, C.J., Offringa, R. J. Exp. Med. (2001) [Pubmed]
  12. A sequential two-step mechanism for the production of the mature p17:p12 form of caspase-3 in vitro. Han, Z., Hendrickson, E.A., Bremner, T.A., Wyche, J.H. J. Biol. Chem. (1997) [Pubmed]
  13. Engineered serine protease inhibitor prevents furin-catalyzed activation of the fusion glycoprotein and production of infectious measles virus. Watanabe, M., Hirano, A., Stenglein, S., Nelson, J., Thomas, G., Wong, T.C. J. Virol. (1995) [Pubmed]
  14. Transactivation of human immunodeficiency virus type 1 long terminal repeats by cell surface tumor necrosis factor alpha. Tadmori, W., Mondal, D., Tadmori, I., Prakash, O. J. Virol. (1991) [Pubmed]
  15. The anti-HIV-1 activity associated with saliva. Shine, N., Konopka, K., Düzgüneş, N. J. Dent. Res. (1997) [Pubmed]
  16. Characterization of cyanobacterial ferredoxin-NADP+ oxidoreductase molecular heterogeneity using chromatofocusing. Serrano, A. Anal. Biochem. (1986) [Pubmed]
  17. cDNA cloning of human plasminogen activator-inhibitor from endothelial cells. Ginsburg, D., Zeheb, R., Yang, A.Y., Rafferty, U.M., Andreasen, P.A., Nielsen, L., Dano, K., Lebo, R.V., Gelehrter, T.D. J. Clin. Invest. (1986) [Pubmed]
  18. Molecular evolution of plasminogen activator inhibitor-1 functional stability. Berkenpas, M.B., Lawrence, D.A., Ginsburg, D. EMBO J. (1995) [Pubmed]
  19. The HNF-4/HNF-1alpha transactivation cascade regulates gene activity and chromatin structure of the human serine protease inhibitor gene cluster at 14q32.1. Rollini, P., Fournier, R.E. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  20. Acylation stabilizes a protease-resistant conformation of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides. Arnould, S., Takahashi, M., Camadro, J.M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  21. Protease-induced immunoregulatory activity of platelet factor 4. Katz, I.R., Thorbecke, G.J., Bell, M.K., Yin, J.Z., Clarke, D., Zucker, M.B. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  22. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Citron, M., Diehl, T.S., Capell, A., Haass, C., Teplow, D.B., Selkoe, D.J. Neuron (1996) [Pubmed]
  23. Urothelial function reconsidered: a role in urinary protein secretion. Deng, F.M., Ding, M., Lavker, R.M., Sun, T.T. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  24. Association of tissue factor pathway inhibitor with human umbilical vein endothelial cells. Hansen, J.B., Olsen, R., Webster, P. Blood (1997) [Pubmed]
  25. Chromosomal elements regulate gene activity and chromatin structure of the human serpin gene cluster at 14q32.1. Marsden, M.D., Fournier, R.E. Mol. Cell. Biol. (2003) [Pubmed]
  26. Expression of bomapin, a novel human serpin, in normal/malignant hematopoiesis and in the monocytic cell lines THP-1 and AML-193. Riewald, M., Chuang, T., Neubauer, A., Riess, H., Schleef, R.R. Blood (1998) [Pubmed]
  27. Disruption of the protein C inhibitor gene results in impaired spermatogenesis and male infertility. Uhrin, P., Dewerchin, M., Hilpert, M., Chrenek, P., Schöfer, C., Zechmeister-Machhart, M., Krönke, G., Vales, A., Carmeliet, P., Binder, B.R., Geiger, M. J. Clin. Invest. (2000) [Pubmed]
  28. Recombinant alpha 1-antitrypsin Pittsburgh (Met 358----Arg) is a potent inhibitor of plasma kallikrein and activated factor XII fragment. Schapira, M., Ramus, M.A., Jallat, S., Carvallo, D., Courtney, M. J. Clin. Invest. (1986) [Pubmed]
  29. Blood coagulation. Dahlbäck, B. Lancet (2000) [Pubmed]
  30. Proteolytic action of thrombin is required for electrical activity-dependent synapse reduction. Liu, Y., Fields, R.D., Festoff, B.W., Nelson, P.G. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  31. Latent tissue plasminogen activator produced by human endothelial cells in culture: evidence for an enzyme-inhibitor complex. Levin, E.G. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  32. A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. Okada, T., Haze, K., Nadanaka, S., Yoshida, H., Seidah, N.G., Hirano, Y., Sato, R., Negishi, M., Mori, K. J. Biol. Chem. (2003) [Pubmed]
  33. TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo. Wisniewski, H.G., Hua, J.C., Poppers, D.M., Naime, D., Vilcek, J., Cronstein, B.N. J. Immunol. (1996) [Pubmed]
  34. Tissue factor pathway inhibitor inhibits aortic smooth muscle cell migration induced by tissue factor/factor VIIa complex. Sato, Y., Asada, Y., Marutsuka, K., Hatakeyama, K., Kamikubo, Y., Sumiyoshi, A. Thromb. Haemost. (1997) [Pubmed]
  35. Production of alpha-1-antichymotrypsin by PSA-containing cells of human prostate epithelium. Bjartell, A., Björk, T., Matikainen, M.T., Abrahamsson, P.A., di Sant'Agnese, A., Lilja, H. Urology (1993) [Pubmed]
  36. A quantitative ELISA for the measurement of complexes of prostate-specific antigen with protein C inhibitor when using a purified standard. España, F., Sanchez-Cuenca, J., Vera, C.D., Estelles, A., Gilabert, J. J. Lab. Clin. Med. (1993) [Pubmed]
  37. Alpha 1-antichymotrypsin binding to Alzheimer A beta peptides is sequence specific and induces fibril disaggregation in vitro. Fraser, P.E., Nguyen, J.T., McLachlan, D.R., Abraham, C.R., Kirschner, D.A. J. Neurochem. (1993) [Pubmed]
  38. Growth hormone receptor C-terminal domains required for growth hormone-induced intracellular free Ca2+ oscillations and gene transcription. Billestrup, N., Bouchelouche, P., Allevato, G., Ilondo, M., Nielsen, J.H. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  39. Mutant p53 can provoke apoptosis in p53-deficient Hep3B cells with delayed kinetics relative to wild-type p53. Stähler, F., Roemer, K. Oncogene (1998) [Pubmed]
  40. Assessment of the interaction between urokinase and reactive site mutants of protein C inhibitor. Jackson, T.P., Cooper, S.T., Church, F.C. J. Protein Chem. (1997) [Pubmed]
  41. Actinobacillus actinomycetemcomitans lipopolysaccharide activates matrix metalloproteinase-2 and increases receptor activator of nuclear factor-kappaB ligand expression in human periodontal ligament cells. Tiranathanagul, S., Yongchaitrakul, T., Pattamapun, K., Pavasant, P. J. Periodontol. (2004) [Pubmed]
  42. Regulation of matrix metalloproteinases and plasminogen activator inhibitor-1 synthesis by plasminogen in cultured human vascular smooth muscle cells. Lee, E., Vaughan, D.E., Parikh, S.H., Grodzinsky, A.J., Libby, P., Lark, M.W., Lee, R.T. Circ. Res. (1996) [Pubmed]
  43. Secretory leukocyte protease inhibitor suppresses the production of monocyte prostaglandin H synthase-2, prostaglandin E2, and matrix metalloproteinases. Zhang, Y., DeWitt, D.L., McNeely, T.B., Wahl, S.M., Wahl, L.M. J. Clin. Invest. (1997) [Pubmed]
  44. Tropical calcific pancreatitis: strong association with SPINK1 trypsin inhibitor mutations. Bhatia, E., Choudhuri, G., Sikora, S.S., Landt, O., Kage, A., Becker, M., Witt, H. Gastroenterology (2002) [Pubmed]
  45. Mammary serine protease inhibitor (Maspin) binds directly to interferon regulatory factor 6: identification of a novel serpin partnership. Bailey, C.M., Khalkhali-Ellis, Z., Kondo, S., Margaryan, N.V., Seftor, R.E., Wheaton, W.W., Amir, S., Pins, M.R., Schutte, B.C., Hendrix, M.J. J. Biol. Chem. (2005) [Pubmed]
  46. Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor. Kawaguchi, T., Qin, L., Shimomura, T., Kondo, J., Matsumoto, K., Denda, K., Kitamura, N. J. Biol. Chem. (1997) [Pubmed]
  47. Uteroglobin suppresses SCCA gene expression associated with allergic asthma. Ray, R., Choi, M., Zhang, Z., Silverman, G.A., Askew, D., Mukherjee, A.B. J. Biol. Chem. (2005) [Pubmed]
  48. Restoration of serine protease-inhibitor interaction by protein engineering. Madison, E.L., Goldsmith, E.J., Gething, M.J., Sambrook, J.F., Gerard, R.D. J. Biol. Chem. (1990) [Pubmed]
  49. Silencing of the hydra serine protease inhibitor Kazal1 gene mimics the human SPINK1 pancreatic phenotype. Chera, S., de Rosa, R., Miljkovic-Licina, M., Dobretz, K., Ghila, L., Kaloulis, K., Galliot, B. J. Cell. Sci. (2006) [Pubmed]
  50. Identification of Amadori-modified plasma proteins in type 2 diabetes and the effect of short-term intensive insulin treatment. Jaleel, A., Halvatsiotis, P., Williamson, B., Juhasz, P., Martin, S., Nair, K.S. Diabetes Care (2005) [Pubmed]
  51. Structure and energetics of protein-protein interactions: the role of conformational heterogeneity in OMTKY3 binding to serine proteases. Horn, J.R., Ramaswamy, S., Murphy, K.P. J. Mol. Biol. (2003) [Pubmed]
  52. Contribution of residues in the reactive site loop of chymotrypsin inhibitor 2 to protein stability and activity. Jackson, S.E., Fersht, A.R. Biochemistry (1994) [Pubmed]
WikiGenes - Universities