Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Ames, R.S. et al.

Ames, Sarau, Chambers, Willette, Aiyar, Romanic, Louden, Foley, Sauermelch, Coatney, Ao, Disa, Holmes, Stadel, Martin, Liu, Glover, Wilson, McNulty, Ellis, Elshourbagy, Shabon, Trill, Hay, Ohlstein, Bergsma, Douglas,

Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

Urotensin-II (U-II) is a vasoactive ' somatostatin-like' cyclic peptide which was originally isolated from fish spinal cords, and which has recently been cloned from man. Here we describe the identification of an orphan human G-protein-coupled receptor homologous to rat GPR14 and expressed predominantly in cardiovascular tissue, which functions as a U-II receptor. Goby and human U-II bind to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human U-II is found within both vascular and cardiac tissue (including coronary atheroma) and effectively constricts isolated arteries from non-human primates. The potency of vasoconstriction of U-II is an order of magnitude greater than that of endothelin-1, making human U-II the most potent mammalian vasoconstrictor identified so far. In vivo, human U-II markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction. Furthermore, as U-II immunoreactivity is also found within central nervous system and endocrine tissues, it may have additional activities.[1]

References

Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Ames, R.S., Sarau, H.M., Chambers, J.K., Willette, R.N., Aiyar, N.V., Romanic, A.M., Louden, C.S., Foley, J.J., Sauermelch, C.F., Coatney, R.W., Ao, Z., Disa, J., Holmes, S.D., Stadel, J.M., Martin, J.D., Liu, W.S., Glover, G.I., Wilson, S., McNulty, D.E., Ellis, C.E., Elshourbagy, N.A., Shabon, U., Trill, J.J., Hay, D.W., Ohlstein, E.H., Bergsma, D.J., Douglas, S.A. Nature (1999) [Pubmed]

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