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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Neuromotor alterations and cerebellar deficits in aged arylsulfatase A-deficient transgenic mice.

Arylsulfatase A (ASA)-deficient (-/-) mice and ASA(+/+) controls were constructed as a transgenic model for the lysosomal storage disease, metachromatic leukodystrophy (MLD). One-year-old ASA(-/-) mice showed impaired rotarod performance and altered walking pattern characterized by a shorter pace, later evolving into more severe ataxia with tremor in 2-year-old mice. Examination of cerebellar histology showed that 2-year-old ASA(-/-) mice have lost most of the calbindin immunoreactivity from their Purkinje cell dendrites and show simplified dendritic architecture. Additionally, ASA-deficient mice lost a substantial proportion of their Purkinje cells. Recordings of unitary potentials and stimulation of climbing fibers on cerebellar slices from 2-year-old mice indicated that, although the main cerebellar synapses seem to be present and functioning physiologically, the climbing fibers of ASA-deficient mice may have enhanced effects on Purkinje cell activity. It is concluded that ambulatory dysfunctions in ASA(-/-) mice might be explained by an imbalance in the consequences of climbing fiber signals upon Purkinje cell activity due to selective neurodegeneration within the cerebellum.[1]


  1. Neuromotor alterations and cerebellar deficits in aged arylsulfatase A-deficient transgenic mice. D'Hooge, R., Hartmann, D., Manil, J., Colin, F., Gieselmann, V., De Deyn, P.P. Neurosci. Lett. (1999) [Pubmed]
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