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Gene Review

Calb1  -  calbindin 1

Mus musculus

Synonyms: Brain-2, CB, Calb, Calb-1, Calbindin, ...
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Disease relevance of Calb1


Psychiatry related information on Calb1


High impact information on Calb1

  • We extended the study to the CB-positive facilitating excitatory mossy fiber-CA3 pyramidal cell synapse [9].
  • Loading the presynaptic terminals with BAPTA or CB rescued the effect of the CB washout [9].
  • The effects of different extracellular Ca2+ concentrations and of EGTA indicated that PPF in CB-containing terminals depended on Ca2+ influx rather than on the initial release probability [9].
  • Such supralinear Ca2+ responses were attributed to the saturation of a large concentration (0.36 mM) of a mobile, high-affinity (dissociation constant, 0.37 microM) Ca2+ buffer with cooperative Ca2+ binding sites, resembling calbindin-D28K, and to an immobile, low-affinity Ca2+ buffer [10].
  • In normal mice, GAD mRNA is present in four sets of neurons in the cerebellar cortex while calbindin mRNA is present only in Purkinje neurons [11].

Chemical compound and disease context of Calb1

  • Neuronal phenotypes in mouse dorsal root ganglion cell cultures: enrichment of substance P and calbindin D-28k expressing neurons in a defined medium [12].
  • The calcium-binding protein calbindin-D28k (CB) is located in midbrain dopaminergic (DA) neurons that are less vulnerable to degeneration in Parkinson's disease and in an animal model of the disorder, the MPTP-treated monkey [13].
  • Cytochalasin B (CB), administered i.p. to C57B1/6 mice in a single dose as a suspension in carboxymethylcellulose 2%/Tween 20 1%, inhibits in a dose-dependent and time-dependent manner the ability of spleen cells to respond to allogeneic P815 mastocytoma tumor cells in vitro [14].
  • To identify the epitope on the type II collagen molecule that induced autoimmune ear disease, electrophysiological and histological studies were carried out in DBA/1J mice immunized with native chick type II collagen (Clln) and cyanogen bromide (CNBr) peptide 1I (CB-I1 peptide) that was cleaved from chicken type II collagen with CNBr digestion [15].
  • Significant differences were also observed between the mouse strains in the concentrations of lithium in plasma, heart, liver, kidney and brain 2 hrs. after a subcutaneous injection of 15.1 or 18.2 mmol/kg LiCl, but the lithium concentrations were not related in an obvious manner to LiCl toxicity [16].

Biological context of Calb1


Anatomical context of Calb1


Associations of Calb1 with chemical compounds

  • Here, we show that CB interacts with IMPase in cerebellar Purkinje neurons, a cell type well known to rely on inositol-1,4,5-trisphosphate-dependent synaptic integration [6].
  • Expression of high levels of exogenous calbindin or calretinin decreased transcription mediated by PCE1 in Purkinje cells 2.5- to 3-fold, whereas the presence of 1 microM ionomycin in the extracellular medium increased expression [17].
  • 5. At E16.5, CB+ cells became more abundant in the lateral and basolateral nuclei than in the basomedial nucleus, showing a pattern very similar to that of gamma-aminobutyric acid (GABA)ergic neurons [24].
  • Calbindin, calretinin, or parvalbumin and 5-bromo-2'-deoxyuridine (BrdU) double labeling showed that calcium binding protein immunopositive neurons in gliotic CA1 area at 60 days were surviving instead of newly generated neurons [23].
  • Undifferentiated P19-cells were stably transfected with the cDNA for CR, CB or PV, induced to differentiate, and then exposed to NMDA, a glutamate-receptor agonist [20].

Co-localisations of Calb1

  • VILIP-3 was found to be abundant in distal and collecting ducts where it partly colocalized with calbindin D28K [25].

Regulatory relationships of Calb1


Other interactions of Calb1

  • Numerical simulations indicate that the residual deviation from a single exponential decay in PV/CB-/- is due to saturation of the Ca2+ indicator dye [18].
  • Degree and time course of PC loss and the subsequent denervation of DCN neurons were monitored by using Calbindin D-28k (Calb) immunocytochemistry [30].
  • In this study, we describe the expression of markers for photoreceptors (recoverin), horizontal cells (calbindin), bipolar cells (protein kinase C; PKC) and cytoskeletal elements pivotal to axonogenesis (beta-tubulin and actin) during perinatal development of mouse retina [31].
  • 5. In contrast, interneurons expressed a subpallial transcription factor (Dlx), contained high levels of GABA, were frequently calbindin(+), and were born throughout corticogenesis (from E10.5 to E16.5) [32].
  • In contrast, calbindin-positive cells in the MZ do not co-express reelin and are not altered in the Pax6 mutant cortex [33].

Analytical, diagnostic and therapeutic context of Calb1


  1. Severe, early and selective loss of a subpopulation of GABAergic inhibitory neurons in experimental transmissible spongiform encephalopathies. Guentchev, M., Groschup, M.H., Kordek, R., Liberski, P.P., Budka, H. Brain Pathol. (1998) [Pubmed]
  2. CCR7, CCR8, CCR9 and CCR10 in the mouse hippocampal CA1 area and the dentate gyrus during and after pilocarpine-induced status epilepticus. Liu, J.X., Cao, X., Tang, Y.C., Liu, Y., Tang, F.R. J. Neurochem. (2007) [Pubmed]
  3. Effect of Brn-3a deficiency on parvalbumin-, calbindin D-28k-, calretinin- and calcitonin gene-related peptide-immunoreactive primary sensory neurons in the trigeminal ganglion. Ichikawa, H., Yamaai, T., Jacobowitz, D.M., Mo, Z., Xiang, M., Sugimoto, T. Neuroscience (2002) [Pubmed]
  4. Vulnerability of midbrain dopaminergic neurons in calbindin-D28k-deficient mice: lack of evidence for a neuroprotective role of endogenous calbindin in MPTP-treated and weaver mice. Airaksinen, M.S., Thoenen, H., Meyer, M. Eur. J. Neurosci. (1997) [Pubmed]
  5. Effect of calbindin-D28K on cyclosporine toxicity in cultured renal proximal tubular cells. Wu, M.J., Lai, L.W., Lien, Y.H. J. Cell. Physiol. (2004) [Pubmed]
  6. Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons. Schmidt, H., Schwaller, B., Eilers, J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Increased calbindin-D28k immunoreactivity in striatal projection neurons of R6/2 Huntington's disease transgenic mice. Sun, Z., Wang, H.B., Deng, Y.P., Lei, W.L., Xie, J.P., Meade, C.A., Del Mar, N., Goldowitz, D., Reiner, A. Neurobiol. Dis. (2005) [Pubmed]
  8. Calcium homeostasis in ageing: studies on the calcium binding protein calbindin D28K. Lally, G., Faull, R.L., Waldvogel, H.J., Ferrari, S., Emson, P.C. Journal of neural transmission (Vienna, Austria : 1996) (1997) [Pubmed]
  9. Ca2+ buffer saturation underlies paired pulse facilitation in calbindin-D28k-containing terminals. Blatow, M., Caputi, A., Burnashev, N., Monyer, H., Rozov, A. Neuron (2003) [Pubmed]
  10. Supralinear Ca2+ signaling by cooperative and mobile Ca2+ buffering in Purkinje neurons. Maeda, H., Ellis-Davies, G.C., Ito, K., Miyashita, Y., Kasai, H. Neuron (1999) [Pubmed]
  11. The abnormal cerebellar organization of Weaver and reeler mice does not affect the cellular distribution of three neuronal mRNAs. Wuenschell, C.W., Tobin, A.J. Neuron (1988) [Pubmed]
  12. Neuronal phenotypes in mouse dorsal root ganglion cell cultures: enrichment of substance P and calbindin D-28k expressing neurons in a defined medium. Ninomiya, T., Barakat-Walter, I., Droz, B. Int. J. Dev. Neurosci. (1994) [Pubmed]
  13. Midbrain dopaminergic neurons in the mouse that contain calbindin-D28k exhibit reduced vulnerability to MPTP-induced neurodegeneration. Liang, C.L., Sinton, C.M., Sonsalla, P.K., German, D.C. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. (1996) [Pubmed]
  14. Cytochalasin-B-induced immunosuppression of murine allogeneic anti-tumor response and the effect of recombinant human interleukin-2. Bogyo, D., Fondy, S.R., Finster, L., Fondy, C., Patil, S., Fondy, T.P. Cancer Immunol. Immunother. (1991) [Pubmed]
  15. Type II collagen-induced autoimmune ear disease in mice: a preliminary report on an epitope of the type II collagen molecule that induced inner ear lesions. Takeda, T., Sudo, N., Kitano, H., Yoo, T.J. The American journal of otology. (1996) [Pubmed]
  16. Lithium chloride toxicity and pharmacodynamics in inbred mice. Smith, D.F. Acta pharmacologica et toxicologica. (1978) [Pubmed]
  17. A calcium responsive element that regulates expression of two calcium binding proteins in Purkinje cells. Arnold, D.B., Heintz, N. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  18. Mutational analysis of dendritic Ca2+ kinetics in rodent Purkinje cells: role of parvalbumin and calbindin D28k. Schmidt, H., Stiefel, K.M., Racay, P., Schwaller, B., Eilers, J. J. Physiol. (Lond.) (2003) [Pubmed]
  19. Embryonic and postnatal development of GABA, calbindin, calretinin, and parvalbumin in the mouse claustral complex. Dávila, J.C., Real, M.A., Olmos, L., Legaz, I., Medina, L., Guirado, S. J. Comp. Neurol. (2005) [Pubmed]
  20. Calretinin and calbindin D-28k delay the onset of cell death after excitotoxic stimulation in transfected P19 cells. D'Orlando, C., Fellay, B., Schwaller, B., Salicio, V., Bloc, A., Gotzos, V., Celio, M.R. Brain Res. (2001) [Pubmed]
  21. Cytological compartmentalization in the staggerer cerebellum, as revealed by calbindin immunohistochemistry for Purkinje cells. Nakagawa, S., Watanabe, M., Isobe, T., Kondo, H., Inoue, Y. J. Comp. Neurol. (1998) [Pubmed]
  22. Ontogeny of calbindin-D28K and calbindin-D9K in the mouse kidney, duodenum, cerebellum and placenta. Shamley, D.R., Opperman, L.A., Buffenstein, R., Ross, F.P. Development (1992) [Pubmed]
  23. Calcium binding protein containing neurons in the gliotic mouse hippocampus with special reference to their afferents from the medial septum and the entorhinal cortex. Tang, F.R., Chia, S.C., Jiang, F.L., Ma, D.L., Chen, P.M., Tang, Y.C. Neuroscience (2006) [Pubmed]
  24. Development of neurons and fibers containing calcium binding proteins in the pallial amygdala of mouse, with special emphasis on those of the basolateral amygdalar complex. Legaz, I., Olmos, L., Real, M.A., Guirado, S., Dávila, J.C., Medina, L. J. Comp. Neurol. (2005) [Pubmed]
  25. Expression of visinin-like protein-3 in mouse kidney. Pribanic, S., Loffing, J., Madjdpour, C., Bacic, D., Gisler, S., Braunewell, K.H., Biber, J., Murer, H. Nephron. Physiology [electronic resource]. (2003) [Pubmed]
  26. Overexpression of calbindin-D28K induces neurite outgrowth in dopaminergic neuronal cells via activation of p38 MAPK. Choi, W.S., Chun, S.Y., Markelonis, G.J., Oh, T.H., Oh, Y.J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  27. Expressions of a calcium-binding protein (spot35/calbindin-D28K) in mouse olfactory cells: possible relationship to neuronal differentiation. Fujiwara, M., Nakamura, H., Kawasaki, M., Nakano, Y., Kuwano, R. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. (1997) [Pubmed]
  28. Postnatal phenotype and localization of spinal cord V1 derived interneurons. Alvarez, F.J., Jonas, P.C., Sapir, T., Hartley, R., Berrocal, M.C., Geiman, E.J., Todd, A.J., Goulding, M. J. Comp. Neurol. (2005) [Pubmed]
  29. Cortical and brainstem neurons containing calcium-binding proteins in a murine model of Duchenne's muscular dystrophy: selective changes in the sensorimotor cortex. Carretta, D., Santarelli, M., Vanni, D., Ciabatti, S., Sbriccoli, A., Pinto, F., Minciacchi, D. J. Comp. Neurol. (2003) [Pubmed]
  30. Dependence of parvalbumin expression on Purkinje cell input in the deep cerebellar nuclei. Bäurle, J., Hoshi, M., Grüsser-Cornehls, U. J. Comp. Neurol. (1998) [Pubmed]
  31. Development of the outer retina in the mouse. Sharma, R.K., O'Leary, T.E., Fields, C.M., Johnson, D.A. Brain Res. Dev. Brain Res. (2003) [Pubmed]
  32. Cajal-Retzius cells in the mouse: transcription factors, neurotransmitters, and birthdays suggest a pallial origin. Hevner, R.F., Neogi, T., Englund, C., Daza, R.A., Fink, A. Brain Res. Dev. Brain Res. (2003) [Pubmed]
  33. Increase in reelin-positive cells in the marginal zone of Pax6 mutant mouse cortex. Stoykova, A., Hatano, O., Gruss, P., Götz, M. Cereb. Cortex (2003) [Pubmed]
  34. Reduced immunoreactivity to calcium-binding proteins in Purkinje cells precedes onset of ataxia in spinocerebellar ataxia-1 transgenic mice. Vig, P.J., Subramony, S.H., Burright, E.N., Fratkin, J.D., McDaniel, D.O., Desaiah, D., Qin, Z. Neurology (1998) [Pubmed]
  35. Relationship between ataxin-1 nuclear inclusions and Purkinje cell specific proteins in SCA-1 transgenic mice. Vig, P.J., Subramony, S.H., Qin, Z., McDaniel, D.O., Fratkin, J.D. J. Neurol. Sci. (2000) [Pubmed]
  36. Presence of calbindin D28K and GAD67 mRNAs in both orthotopic and ectopic Purkinje cells of staggerer mice suggests that staggerer acts after the onset of cytodifferentiation. Frantz, G.D., Wuenschell, C.W., Messer, A., Tobin, A.J. J. Neurosci. Res. (1996) [Pubmed]
  37. Translocation of cytochrome c during cerebellar degeneration in Lurcher and weaver mutant mice. Frischmuth, S., Kranda, K., B??urle, J. Brain Res. Bull. (2006) [Pubmed]
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