The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Arsa  -  arylsulfatase A

Mus musculus

Synonyms: AS-A, ASA, AW212749, Arylsulfatase A, As-2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Arsa


High impact information on Arsa


Chemical compound and disease context of Arsa


Biological context of Arsa


Anatomical context of Arsa


Associations of Arsa with chemical compounds


Other interactions of Arsa

  • Recordings of unitary potentials and stimulation of climbing fibers on cerebellar slices from 2-year-old mice indicated that, although the main cerebellar synapses seem to be present and functioning physiologically, the climbing fibers of ASA-deficient mice may have enhanced effects on Purkinje cell activity [20].
  • One-year-old ASA(-/-) mice showed impaired rotarod performance and altered walking pattern characterized by a shorter pace, later evolving into more severe ataxia with tremor in 2-year-old mice [20].
  • The enzymatic activity of five acid hydrolases: acid phosphatase, arylsulfatase A, deoxyribonuclease, beta-glucuronidase, and cathepsin D, was assayed in fetal (fifteenth and eighteenth days of pregnancy) and neonatal (Days 0, 5, 10, and 15 post-partum) mouse liver [21].
  • Age-related changes in cerebroside sulfotransferase (measured in brain) and arylsulfatase A and cerebroside B-galactosidase (measured in brain and liver) were the same for shiverer and control mice [22].
  • The developmental patterns and the activities of arylsulfatase A were, however, normal in the cerebrum and cerebellum of jimpy mice [23].

Analytical, diagnostic and therapeutic context of Arsa


  1. Phenotype of arylsulfatase A-deficient mice: relationship to human metachromatic leukodystrophy. Hess, B., Saftig, P., Hartmann, D., Coenen, R., Lüllmann-Rauch, R., Goebel, H.H., Evers, M., von Figura, K., D'Hooge, R., Nagels, G., De Deyn, P., Peters, C., Gieselmann, V. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Decline in brainstem auditory-evoked potentials coincides with loss of spiral ganglion cells in arylsulfatase A-deficient mice. D'Hooge, R., Coenen, R., Gieselmann, V., Lüllmann-Rauch, R., De Deyn, P.P. Brain Res. (1999) [Pubmed]
  3. Hyperactivity, neuromotor defects, and impaired learning and memory in a mouse model for metachromatic leukodystrophy. D'Hooge, R., Van Dam, D., Franck, F., Gieselmann, V., De Deyn, P.P. Brain Res. (2001) [Pubmed]
  4. Arylsulfatases of human-lung tumors transplanted into athymic mice. Cancer-associated modification of arylsulfatase B variant. Gasa, S., Makita, A., Kameya, T., Kodama, T., Koide, T., Tsumuraya, M., Komai, T. Eur. J. Biochem. (1981) [Pubmed]
  5. In vivo gene therapy of metachromatic leukodystrophy by lentiviral vectors: correction of neuropathology and protection against learning impairments in affected mice. Consiglio, A., Quattrini, A., Martino, S., Bensadoun, J.C., Dolcetta, D., Trojani, A., Benaglia, G., Marchesini, S., Cestari, V., Oliverio, A., Bordignon, C., Naldini, L. Nat. Med. (2001) [Pubmed]
  6. Correction of metachromatic leukodystrophy in the mouse model by transplantation of genetically modified hematopoietic stem cells. Biffi, A., De Palma, M., Quattrini, A., Del Carro, U., Amadio, S., Visigalli, I., Sessa, M., Fasano, S., Brambilla, R., Marchesini, S., Bordignon, C., Naldini, L. J. Clin. Invest. (2004) [Pubmed]
  7. Defective endoplasmic reticulum-resident membrane protein CLN6 affects lysosomal degradation of endocytosed arylsulfatase A. Heine, C., Koch, B., Storch, S., Kohlschütter, A., Palmer, D.N., Braulke, T. J. Biol. Chem. (2004) [Pubmed]
  8. Translational control of arylsulfatase A expression in mouse testis. Kreysing, J., Polten, A., Lukatela, G., Matzner, U., von Figura, K., Gieselmann, V. J. Biol. Chem. (1994) [Pubmed]
  9. Enzyme replacement improves nervous system pathology and function in a mouse model for metachromatic leukodystrophy. Matzner, U., Herbst, E., Hedayati, K.K., Lüllmann-Rauch, R., Wessig, C., Schröder, S., Eistrup, C., Möller, C., Fogh, J., Gieselmann, V. Hum. Mol. Genet. (2005) [Pubmed]
  10. Biochemical characterization of arylsulfatases detected in granulomatous inflammation. Higuchi, M., Ito, Y., Fukuyama, K., Epstein, W.L. Exp. Mol. Pathol. (1984) [Pubmed]
  11. Coexpression of formylglycine-generating enzyme is essential for synthesis and secretion of functional arylsulfatase A in a mouse model of metachromatic leukodystrophy. Takakusaki, Y., Hisayasu, S., Hirai, Y., Shimada, T. Hum. Gene Ther. (2005) [Pubmed]
  12. Enhancement of sulphatide metabolism in the hypertrophied kidney of C3H/He mouse with reference to [Na+, K+]-dependent ATPase. Umeda, T., Egawa, K., Nagai, Y. Jpn. J. Exp. Med. (1976) [Pubmed]
  13. Retrovirally expressed human arylsulfatase A corrects the metabolic defect of arylsulfatase A-deficient mouse cells. Matzner, U., Habetha, M., Gieselmann, V. Gene Ther. (2000) [Pubmed]
  14. Acquisition of arylsulfatase A onto the mouse sperm surface during epididymal transit. Weerachatyanukul, W., Xu, H., Anupriwan, A., Carmona, E., Wade, M., Hermo, L., da Silva, S.M., Rippstein, P., Sobhon, P., Sretarugsa, P., Tanphaichitr, N. Biol. Reprod. (2003) [Pubmed]
  15. Comparative studies of rodent anionic arylsulfatases. Thompson, D.B., Daniel, W.L., Glaser, J.H. Comp. Biochem. Physiol., B (1985) [Pubmed]
  16. Oligodendroglial progenitor cell therapy limits central neurological deficits in mice with metachromatic leukodystrophy. Givogri, M.I., Galbiati, F., Fasano, S., Amadio, S., Perani, L., Superchi, D., Morana, P., Del Carro, U., Marchesini, S., Brambilla, R., Wrabetz, L., Bongarzone, E. J. Neurosci. (2006) [Pubmed]
  17. Mammalian arylsulfatases A and B: relative rates of hydrolysis of artificial substrates. Thompson, D.B., Daniel, W.L. Experientia (1986) [Pubmed]
  18. In vitro mutagenesis of potential N-glycosylation sites of arylsulfatase A. Effects on glycosylation, phosphorylation, and intracellular sorting. Gieselmann, V., Schmidt, B., von Figura, K. J. Biol. Chem. (1992) [Pubmed]
  19. Reduced brain cholesterol content in arylsulfatase A-deficient mice. Lütjohann, D., Harzer, K., Gieselmann, V., Eckhardt, M. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  20. Neuromotor alterations and cerebellar deficits in aged arylsulfatase A-deficient transgenic mice. D'Hooge, R., Hartmann, D., Manil, J., Colin, F., Gieselmann, V., De Deyn, P.P. Neurosci. Lett. (1999) [Pubmed]
  21. The development of lysosomal apparatus. I. Lysosomal enzyme activities in the liver of mice at perinatal stages and those of their mothers. Mazzei, H.R., Bertini, F. J. Cell. Physiol. (1978) [Pubmed]
  22. Developmental dissociation of myelin synthesis and "myelin-associated" enzyme activities in the shiverer mouse. Bird, T.D., Farrell, D.F., Stranahan, S., Austin, E. Neurochem. Res. (1980) [Pubmed]
  23. Net sulfatide synthesis, galactosylceramide sulfotransferase and arylsulfatase A activity in the developing cerebrum and cerebellum of normal mice and myelin-deficient jimpy mice. Burkart, T., Wiesmann, U.N., Siegrist, H.P., Herschkowitz, N.N. Biochim. Biophys. Acta (1981) [Pubmed]
  24. Structure of the mouse arylsulfatase A gene and cDNA. Kreysing, J., Polten, A., Hess, B., von Figura, K., Menz, K., Steiner, F., Gieselmann, V. Genomics (1994) [Pubmed]
WikiGenes - Universities