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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Recent advances in xenotransplantation.

The major barrier to clinically successful pig-to-human xenotransplantation is antibody- and complement-dependent hyperacute rejection, known to be due to host anti-Galalpha(1,3)Gal antibodies. Strategies aimed at eliminating hyperacute rejection involve transgenic approaches to eliminate or reduce expression of Galalpha(1,3)Gal or to reduce complement activation; some of these are now in clinical trials in primates. Another important role of Galalpha(1,3)Gal that is becoming more evident is in antibody-dependent and -independent xenograft rejection that is mediated by natural killer cells and monocytes.[1]


  1. Recent advances in xenotransplantation. Sandrin, M.S., McKenzie, I.F. Curr. Opin. Immunol. (1999) [Pubmed]
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