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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Nuclear proliferation in syncytia during avian reovirus replication.

Cultured chick embryonic fibroblasts formed syncytia after infection with avian reovirus (ARV) strain 58-132. Mitotic figures were occasionally observed within the syncytia. In addition, many nuclei in the syncytia incorporated 5-bromo-2'-deoxyuridine (BrdU), a DNA replication marker, indicating that they were in the S-phase of the cell cycle. These observations suggested that the nuclei within ARV-induced syncytia originated from nuclear endomitosis without cell division, as well as from cell fusion.[1]

References

  1. Nuclear proliferation in syncytia during avian reovirus replication. Tsukamoto, Y., Kotani, T., Kohama, K., Sakuma, S., Sasaki, F. Can. J. Vet. Res. (1999) [Pubmed]
 
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