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Axworthy, D.B. et al.

Axworthy, Reno, Hylarides, Mallett, Theodore, Gustavson, Su, Hobson, Beaumier, Fritzberg,

Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity.

A covalent conjugate (NR-LU-10/SA) was prepared between streptavidin (SA) and NR-LU-10, a mAb that binds an antigen expressed on the surface of most human carcinomas. NR-LU-10/SA was injected into nude mice bearing human tumor xenografts. Injection of biotinylated galactosyl-human serum albumin reduced the circulating levels of conjugate by 95%. Subsequent administration of (90)Y-1,4,7, 10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-biotin achieved peak uptake at the tumor within 2 hr while >80% of the radioactivity was eliminated in the urine. A single dose of 600-800 microCi of (90)Y-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-biotin produced cures in 10/10 mice with established (>200 mm(3)) s.c. human small cell lung or colon cancer xenografts and 8/10 cures in mice with human breast cancer xenografts without significant toxicity.[1]

References

Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity. Axworthy, D.B., Reno, J.M., Hylarides, M.D., Mallett, R.W., Theodore, L.J., Gustavson, L.M., Su, F., Hobson, L.J., Beaumier, P.L., Fritzberg, A.R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]

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