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Chemical Compound Review

Yttrium Radioisotopes     yttrium

Synonyms: Yttrium-90, Y-90, HSDB 7406, AC1L2XG5, D015021000, ...
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Disease relevance of yttrium


Psychiatry related information on yttrium

  • To overcome the problem of tumor heterogeneity, we conducted a pilot evaluation of the safety and effectiveness of yttrium 90 (90Y)-labeled anti-Id and shared Id (sId) MoAbs in non-Hodgkin's B-cell lymphoma [6].

High impact information on yttrium


Chemical compound and disease context of yttrium


Biological context of yttrium


Anatomical context of yttrium


Associations of yttrium with other chemical compounds

  • Effects of hepatic arterial yttrium-90 microsphere administration alone and combined with regional bromodeoxyuridine infusion in dogs [23].
  • Atomistic models for CeO(2)(111), (110), and (100) nanoparticles, supported on yttrium-stabilized zirconia [24].
  • Evaluation of indium-111- and yttrium-90-labeled linker-immunoconjugates in nude mice and dogs [25].
  • Treatment of the recently reported potassium salt [K(thf)(n)][N(PPh(2))(2)] (n=1.25, 1.5) with anhydrous yttrium or lanthanide trichlorides in THF leads after crystallization from THF/n-pentane (1:2) to the monosubstituted diphosphanylamide complexes [LnCl(2)[(Ph(2)P)(2)N](thf)(3)] (Ln=Y, Sm, Er, Yb) [26].
  • Prior to the selective transport of a metal ion through the liquid membrane in the microchannel, the forward and backward extraction of yttrium and zinc ions was investigated in a two-phase flow on a microfluidic device using 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester (commercial name, PC-88A) as an extractant [27].

Gene context of yttrium


Analytical, diagnostic and therapeutic context of yttrium


  1. Endoluminal beta-radiation therapy for the prevention of coronary restenosis after balloon angioplasty. The Dose-Finding Study Group. Verin, V., Popowski, Y., de Bruyne, B., Baumgart, D., Sauerwein, W., Lins, M., Kovacs, G., Thomas, M., Calman, F., Disco, C., Serruys, P.W., Wijns, W. N. Engl. J. Med. (2001) [Pubmed]
  2. Yttrium-90 microspheres for the treatment of hepatocellular carcinoma. Geschwind, J.F., Salem, R., Carr, B.I., Soulen, M.C., Thurston, K.G., Goin, K.A., Van Buskirk, M., Roberts, C.A., Goin, J.E. Gastroenterology (2004) [Pubmed]
  3. Randomized comparison of Nd YAG laser, heater probe, and no endoscopic therapy for bleeding peptic ulcers. Matthewson, K., Swain, C.P., Bland, M., Kirkham, J.S., Bown, S.G., Northfield, T.C. Gastroenterology (1990) [Pubmed]
  4. Cure of human carcinoma xenografts by a single dose of pretargeted yttrium-90 with negligible toxicity. Axworthy, D.B., Reno, J.M., Hylarides, M.D., Mallett, R.W., Theodore, L.J., Gustavson, L.M., Su, F., Hobson, L.J., Beaumier, P.L., Fritzberg, A.R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  5. Synergy of Taxol and radioimmunotherapy with yttrium-90-labeled chimeric L6 antibody: efficacy and toxicity in breast cancer xenografts. DeNardo, S.J., Kukis, D.L., Kroger, L.A., O'Donnell, R.T., Lamborn, K.R., Miers, L.A., DeNardo, D.G., Meares, C.F., DeNardo, G.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  6. Radioimmunotherapy of relapsed B-cell lymphoma with yttrium 90 anti-idiotype monoclonal antibodies. White, C.A., Halpern, S.E., Parker, B.A., Miller, R.A., Hupf, H.B., Shawler, D.L., Collins, H.A., Royston, I. Blood (1996) [Pubmed]
  7. Modulation by beta-aminopropionitrile of vessel luminal narrowing and structural abnormalities in arterial wall collagen in a rabbit model of conventional balloon angioplasty versus laser balloon angioplasty. Spears, J.R., Zhan, H., Khurana, S., Karvonen, R.L., Reiser, K.M. J. Clin. Invest. (1994) [Pubmed]
  8. Yttrium-90-labelled somatostatin-analogue for cancer treatment. Otte, A., Mueller-Brand, J., Dellas, S., Nitzsche, E.U., Herrmann, R., Maecke, H.R. Lancet (1998) [Pubmed]
  9. Phase I trial of yttrium-90-labeled anti-prostate-specific membrane antigen monoclonal antibody J591 for androgen-independent prostate cancer. Milowsky, M.I., Nanus, D.M., Kostakoglu, L., Vallabhajosula, S., Goldsmith, S.J., Bander, N.H. J. Clin. Oncol. (2004) [Pubmed]
  10. Indium-111- and yttrium-90-labeled human monoclonal immunoglobulin M targeting of human ovarian cancer in mice. Borchardt, P.E., Quadri, S.M., Freedman, R.S., Vriesendorp, H.M. J. Nucl. Med. (1998) [Pubmed]
  11. 90Y-DOTA-hLL2: an agent for radioimmunotherapy of non-Hodgkin's lymphoma. Griffiths, G.L., Govindan, S.V., Sharkey, R.M., Fisher, D.R., Goldenberg, D.M. J. Nucl. Med. (2003) [Pubmed]
  12. Large-volume liver metastases from neuroendocrine tumors: hepatic intraarterial 90Y-DOTA-lanreotide as effective palliative therapy. McStay, M.K., Maudgil, D., Williams, M., Tibballs, J.M., Watkinson, A.F., Caplin, M.E., Buscombe, J.R. Radiology. (2005) [Pubmed]
  13. Ongoing investigations and new uses of radioimmunotherapy in the treatment of non-Hodgkin's lymphoma. Meredith, R.F. Int. J. Radiat. Oncol. Biol. Phys. (2006) [Pubmed]
  14. Chromosome aberrations and intra-articular yttrium-90. Lloyd, D.C., Reeder, E.J. Lancet (1978) [Pubmed]
  15. Development and characterization of anti-renal cell carcinoma x antichelate bispecific monoclonal antibodies for two-phase targeting of renal cell carcinoma. Kranenborg, M.H., Boerman, O.C., Oosterwijk-Wakka, J.C., de Weijert, M.C., Corstens, F.H., Oosterwijk, E. Cancer Res. (1995) [Pubmed]
  16. Structural dependence of thermodynamics of alkene binding to yttrium alkyl complexes and of kinetics of alkyl migration to coordinated alkenes. Casey, C.P., Tunge, J.A., Lee, T.Y., Fagan, M.A. J. Am. Chem. Soc. (2003) [Pubmed]
  17. Enhanced therapeutic index of radioimmunotherapy (RIT) in prostate cancer patients: comparison of radiation dosimetry for 1,4,7,10-tetraazacyclododecane-N,N',N",N"'-tetraacetic acid (DOTA)-peptide versus 2IT-DOTA monoclonal antibody linkage for RIT. DeNardo, S.J., DeNardo, G.L., Yuan, A., Richman, C.M., O'Donnell, R.T., Lara, P.N., Kukis, D.L., Natarajan, A., Lamborn, K.R., Jacobs, F., Siantar, C.L. Clin. Cancer Res. (2003) [Pubmed]
  18. Polyoxometalate-supported Y- and YbIII-hydroxo/oxo clusters from carbonate-assisted hydrolysis. Fang, X., Anderson, T.M., Benelli, C., Hill, C.L. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
  19. Yttrium 90-labeled antiferritin followed by high-dose chemotherapy and autologous bone marrow transplantation for poor-prognosis Hodgkin's disease. Bierman, P.J., Vose, J.M., Leichner, P.K., Quadri, S.M., Armitage, J.O., Klein, J.L., Abrams, R.A., Dicke, K.A., Vriesendorp, H.M. J. Clin. Oncol. (1993) [Pubmed]
  20. Radiotherapy in mice with yttrium-90-labeled anti-Ly1 monoclonal antibody: therapy of the T cell lymphoma EL4. Schmidberger, H., Buchsbaum, D.J., Blazar, B.R., Everson, P., Vallera, D.A. Cancer Res. (1991) [Pubmed]
  21. Hyaluronic acid production by irradiated human synovial fibroblasts. Yaron, M., Yaron, I., Levita, M., Herzberg, M. Arthritis Rheum. (1977) [Pubmed]
  22. Experimental and clinical use of the YAG laser in the management of pulmonary neoplasms. Wolfe, W.G., Cole, P.H., Sabiston, D.C. Ann. Surg. (1984) [Pubmed]
  23. Effects of hepatic arterial yttrium-90 microsphere administration alone and combined with regional bromodeoxyuridine infusion in dogs. Wollner, I.S., Knutsen, C.A., Ullrich, K.A., Chrisp, C.E., Juni, J.E., Andrews, J.C., Tuscan, M.J., Stetson, P.L., Ensminger, W.D. Cancer Res. (1987) [Pubmed]
  24. Atomistic models for CeO(2)(111), (110), and (100) nanoparticles, supported on yttrium-stabilized zirconia. Sayle, D.C., Maicaneanu, S.A., Watson, G.W. J. Am. Chem. Soc. (2002) [Pubmed]
  25. Evaluation of indium-111- and yttrium-90-labeled linker-immunoconjugates in nude mice and dogs. Quadri, S.M., Vriesendorp, H.M., Leichner, P.K., Williams, J.R. J. Nucl. Med. (1993) [Pubmed]
  26. Yttrium and lanthanide diphosphanylamides: syntheses and structures of complexes with one [(Ph2P)2N]- ligand in the coordination sphere. Roesky, P.W., Gamer, M.T., Marinos, N. Chemistry (Weinheim an der Bergstrasse, Germany) (2004) [Pubmed]
  27. Liquid membrane operations in a microfluidic device for selective separation of metal ions. Maruyama, T., Matsushita, H., Uchida, J., Kubota, F., Kamiya, N., Goto, M. Anal. Chem. (2004) [Pubmed]
  28. Experience with indium-111 and yttrium-90-labeled somatostatin analogs. Virgolini, I., Traub, T., Novotny, C., Leimer, M., Füger, B., Li, S.R., Patri, P., Pangerl, T., Angelberger, P., Raderer, M., Burggasser, G., Andreae, F., Kurtaran, A., Dudczak, R. Curr. Pharm. Des. (2002) [Pubmed]
  29. The somatostatin receptor-targeted radiotherapeutic [90Y-DOTA-DPhe1, Tyr3]octreotide (90Y-SMT 487) eradicates experimental rat pancreatic CA 20948 tumours. Stolz, B., Weckbecker, G., Smith-Jones, P.M., Albert, R., Raulf, F., Bruns, C. European journal of nuclear medicine. (1998) [Pubmed]
  30. Effect of yttrium-90-labeled anti-carcinoembryonic antigen monoclonal antibody on the morphology and phenotype of human tumors grown as peritoneal carcinomatosis in athymic mice. Esteban, J.M., Hyams, D.M., Beatty, B.G., Wanek, P., Beatty, J.D. Cancer (1989) [Pubmed]
  31. Lack of rise in serum prolactin following yttrium-90 interstitial irradiation for acromegaly. Clark, A.J., Chahal, P., Mashiter, K., Joplin, G.F. Clin. Endocrinol. (Oxf) (1983) [Pubmed]
  32. Laser-induced alteration of collagen substructure allows microsurgical tissue welding. Schober, R., Ulrich, F., Sander, T., Dürselen, H., Hessel, S. Science (1986) [Pubmed]
  33. A controlled trial of intra-articular radiocolloids versus surgical synovectomy in persistent synovitis. Gumpel, J.M., Roles, N.C. Lancet (1975) [Pubmed]
  34. Experimental comparison of endoscopic yttrium-aluminum-garnet laser, electrosurgery, and heater probe for canine gut arterial coagulation. Importance of compression and avoidance of erosion. Johnston, J.H., Jensen, D.M., Auth, D. Gastroenterology (1987) [Pubmed]
  35. Subsequent chemotherapy regimens are well tolerated after radioimmunotherapy with yttrium-90 ibritumomab tiuxetan for non-Hodgkin's lymphoma. Ansell, S.M., Ristow, K.M., Habermann, T.M., Wiseman, G.A., Witzig, T.E. J. Clin. Oncol. (2002) [Pubmed]
  36. Randomized controlled trial of yttrium-90-labeled ibritumomab tiuxetan radioimmunotherapy versus rituximab immunotherapy for patients with relapsed or refractory low-grade, follicular, or transformed B-cell non-Hodgkin's lymphoma. Witzig, T.E., Gordon, L.I., Cabanillas, F., Czuczman, M.S., Emmanouilides, C., Joyce, R., Pohlman, B.L., Bartlett, N.L., Wiseman, G.A., Padre, N., Grillo-López, A.J., Multani, P., White, C.A. J. Clin. Oncol. (2002) [Pubmed]
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