- The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. Gray, T.A., Hernandez, L., Carey, A.H., Schaldach, M.A., Smithwick, M.J., Rus, K., Marshall Graves, J.A., Stewart, C.L., Nicholls, R.D. Genomics (2000)