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Gene Review

TRB  -  T cell receptor beta locus

Homo sapiens

Synonyms: TCRB, TRB@
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Disease relevance of TRB@


High impact information on TRB@


Chemical compound and disease context of TRB@

  • The benzimidazole D-ribonucleosides TCRB and BDCRB are potent and selective inhibitors of human cytomegalovirus (HCMV) replication [11].
  • The BIOMED-2 Concerted Action BMH4-CT98-3936 on 'Polymerase chain reaction (PCR)-based clonality studies for early diagnosis of lymphoproliferative disorders' developed standardized PCR protocols for detection of immunoglobulin (Ig) and T-cell receptor (TCR) rearrangements, including TCR beta (TCRB) [12].
  • Evaluation of the 2-chloro analog of BDCRB (TCRB) which is less potent against HCMV, its 5'-deoxy analog (5'-dTCRB) which is more potent, and the 2-unsubstituted compound (DRB) gave the following order of haemopoietic toxicity: DRB > TCRB > or = 5'-dTCRB > BDCRB [13].

Biological context of TRB@

  • The clonal TCRB, TCRG and TCRD gene rearrangements were analyzed for gene segment usage and for the size and composition of their junctional regions [14].
  • For chromosomal mapping of the Ig and TcR loci including the IGK, IGL, and TRB on the cat genome, we performed PCR screening of DNAs from 37 cat x rodent somatic cell hybrids by using specific primers for the given genes [15].
  • All but one patient-derived conserved sequences originated from acute stage ReA-patients, and were not present among approximately 3800 other human TCRB sequences in the database [16].
  • Two-point linkage analysis between Thomsen disease and TCRB showed a maximum cumulative lod score of 3.963 at a recombination fraction of .10 (1-lod support interval .048-.275) [1].
  • In addition, we observed considerable linkage disequilibrium (LD) (r(2) > 0.1) over distances of approximately 30 kb in TCRB, and, in general, the distribution of r(2) as a function of physical distance was in close agreement with neutral coalescent simulations [17].

Anatomical context of TRB@

  • To test the impact of CD on the regional distribution of expanded T cells, this study analyzed the T cell receptor beta (TCRB) repertoire within colonic biopsy specimens from 12 CD patients and 6 noninflammatory controls by TCR spectratyping [18].
  • TCRG and TCRB mRNAs were expressed in the cells of precursor T- but not B-cell leukemia patients studied [19].
  • On Southern blot analysis, the mature T-cell leukemia cells studied had rearranged TCRG and TCRB while IGHJ remained as in the germ line [19].
  • The T-cell receptor (TCR) plays a central role in the immune system, and > 90% of human T cells present a receptor that consists of the alpha TCR subunit (TCRA) and the beta subunit (TCRB) [17].
  • Chromosomal in situ hybridization of a Hodgkin's disease-derived cell line (L540) using DNA probes for TCRA, TCRB, MET, and rRNA [20].

Associations of TRB@ with chemical compounds

  • The RR was 1.67 for allele C1 at TCRA1, 3.35 for allele D2 at TCRA2, 1.66 for allele B2 at TCRG, and 1.35 for allele B at TCRB, showing no significant association [10].
  • Using the multiplex PCR tubes of the BIOMED-2 Concerted Action, TCRB gene rearrangements were detected in 35% of childhood (n=161) and adult (n=172) precursor-B-ALL patients (Vbeta-(Dbeta)-Jbeta in 25%; Dbeta-Jbeta in 15%) [5].
  • Atlantic salmon (Salmo salar) cDNAs encoding the T-cell antigen receptor beta chain (TCRB) were isolated from leukocyte RNA by reverse transcription - polymerase chain reaction (RT-PCR) [21].
  • These findings are consistent with genetic mapping of resistance to TCRB (2,5,6-trichloro-1-beta-D-ribofuranosyl benzimidazole) (P. M. Krosky et al., J. Virol. 72:4721-4728, 1998) and provide further indirect evidence that proteins encoded by UL89 and UL56 function as two subunits of the CMV terminase [22].
  • Regional cerebral muscarinic cholinergic receptor binding was quantified in normal young and elderly subjects employing the muscarinic antagonist radioligand [11C]tropanyl benzilate (TRB) [23].

Enzymatic interactions of TRB@


Other interactions of TRB@


Analytical, diagnostic and therapeutic context of TRB@


  1. Linkage of Thomsen disease to the T-cell-receptor beta (TCRB) locus on chromosome 7q35. Abdalla, J.A., Casley, W.L., Cousin, H.K., Hudson, A.J., Murphy, E.G., Cornélis, F.C., Hashimoto, L., Ebers, G.C. Am. J. Hum. Genet. (1992) [Pubmed]
  2. Chromosome translocations involving band 7q35 or 7p15 in childhood T-cell leukemia/lymphoma. Kaneko, Y., Maseki, N., Homma, C., Sakurai, M., Mizutani, S., Takeda, T., Shikano, T., Fujimoto, T., Yaoi, K., Shimokawa, T. Blood (1988) [Pubmed]
  3. Exploring the mammalian neuromuscular system by analysis of mutations: spinal muscular atrophy and myotonia. Jockusch, H., Kaupmann, K., Gronemeier, M., Schleef, M., Klocke, R. Prog. Neurobiol. (1994) [Pubmed]
  4. Detection of T cell receptor beta (TCRB) gene rearrangement patterns in T cell malignancies by Southern blot analysis. Langerak, A.W., Wolvers-Tettero, I.L., van Dongen, J.J. Leukemia (1999) [Pubmed]
  5. TCRB gene rearrangements in childhood and adult precursor-B-ALL: frequency, applicability as MRD-PCR target, and stability between diagnosis and relapse. van der Velden, V.H., Brüggemann, M., Hoogeveen, P.G., de Bie, M., Hart, P.G., Raff, T., Pfeifer, H., Lüschen, S., Szczepański, T., van Wering, E.R., Kneba, M., van Dongen, J.J. Leukemia (2004) [Pubmed]
  6. A family of candidate taste receptors in human and mouse. Matsunami, H., Montmayeur, J.P., Buck, L.B. Nature (2000) [Pubmed]
  7. The skeletal muscle chloride channel in dominant and recessive human myotonia. Koch, M.C., Steinmeyer, K., Lorenz, C., Ricker, K., Wolf, F., Otto, M., Zoll, B., Lehmann-Horn, F., Grzeschik, K.H., Jentsch, T.J. Science (1992) [Pubmed]
  8. Avidity for antigen shapes clonal dominance in CD8+ T cell populations specific for persistent DNA viruses. Price, D.A., Brenchley, J.M., Ruff, L.E., Betts, M.R., Hill, B.J., Roederer, M., Koup, R.A., Migueles, S.A., Gostick, E., Wooldridge, L., Sewell, A.K., Connors, M., Douek, D.C. J. Exp. Med. (2005) [Pubmed]
  9. A genetically determined insertion/deletion related polymorphism in human T cell receptor beta chain (TCRB) includes functional variable gene segments. Zhao, T.M., Whitaker, S.E., Robinson, M.A. J. Exp. Med. (1994) [Pubmed]
  10. T-cell receptor variable genes and genetic susceptibility to celiac disease: an association and linkage study. Roschmann, E., Wienker, T.F., Gerok, W., Volk, B.A. Gastroenterology (1993) [Pubmed]
  11. Role of a mutation in human cytomegalovirus gene UL104 in resistance to benzimidazole ribonucleosides. Komazin, G., Townsend, L.B., Drach, J.C. J. Virol. (2004) [Pubmed]
  12. Validation of BIOMED-2 multiplex PCR tubes for detection of TCRB gene rearrangements in T-cell malignancies. Droese, J., Langerak, A.W., Groenen, P.J., Brüggemann, M., Neumann, P., Wolvers-Tettero, I.L., van Altena, M.C., Kneba, M., van Dongen, J.J. Leukemia (2004) [Pubmed]
  13. Comparison of benzimidazole nucleosides and ganciclovir on the in vitro proliferation and colony formation of human bone marrow progenitor cells. Nassiri, M.R., Emerson, S.G., Devivar, R.V., Townsend, L.B., Drach, J.C., Taichman, R.S. Br. J. Haematol. (1996) [Pubmed]
  14. Human T-cell lines with well-defined T-cell receptor gene rearrangements as controls for the BIOMED-2 multiplex polymerase chain reaction tubes. Sandberg, Y., Verhaaf, B., van Gastel-Mol, E.J., Wolvers-Tettero, I.L., de Vos, J., Macleod, R.A., Noordzij, J.G., Dik, W.A., van Dongen, J.J., Langerak, A.W. Leukemia (2007) [Pubmed]
  15. Cloning and mapping of cat (Felis catus) immunoglobulin and T-cell receptor genes. Cho, K., Youn, H.Y., Okuda, M., Satoh, H., Cevario, S., O'Brien, S.J., Watari, T., Tsujimoto, H., Hasegawa, A. Immunogenetics (1998) [Pubmed]
  16. Conserved TCR beta chain usage in reactive arthritis; evidence for selection by a putative HLA-B27-associated autoantigen. May, E., Dulphy, N., Frauendorf, E., Duchmann, R., Bowness, P., Lopez de Castro, J.A., Toubert, A., Märker-Hermann, E. Tissue Antigens (2002) [Pubmed]
  17. Sequence variation and linkage disequilibrium in the human T-cell receptor beta (TCRB) locus. Subrahmanyan, L., Eberle, M.A., Clark, A.G., Kruglyak, L., Nickerson, D.A. Am. J. Hum. Genet. (2001) [Pubmed]
  18. Regional variation of the alphabeta T cell repertoire in the colon of healthy individuals and patients with Crohn's disease. May, E., Lambert, C., Holtmeier, W., Hennemann, A., Zeitz, M., Duchmann, R. Hum. Immunol. (2002) [Pubmed]
  19. Immunoglobulin and T-cell receptor gene rearrangement and expression in human lymphoid leukemia cells at different stages of maturation. Davey, M.P., Bongiovanni, K.F., Kaulfersch, W., Quertermous, T., Seidman, J.G., Hershfield, M.S., Kurtzberg, J., Haynes, B.F., Davis, M.M., Waldmann, T.A. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  20. Chromosomal in situ hybridization of a Hodgkin's disease-derived cell line (L540) using DNA probes for TCRA, TCRB, MET, and rRNA. Fonatsch, C., Gradl, G., Kolbus, U., Rieder, H., Tesch, H. Hum. Genet. (1990) [Pubmed]
  21. Cloning of T-cell antigen receptor beta chain cDNAs from Atlantic salmon (Salmo salar). Hordvik, I., Jacob, A.L., Charlemagne, J., Endresen, C. Immunogenetics (1996) [Pubmed]
  22. A novel nonnucleoside inhibitor specifically targets cytomegalovirus DNA maturation via the UL89 and UL56 gene products. Buerger, I., Reefschlaeger, J., Bender, W., Eckenberg, P., Popp, A., Weber, O., Graeper, S., Klenk, H.D., Ruebsamen-Waigmann, H., Hallenberger, S. J. Virol. (2001) [Pubmed]
  23. In vivo quantification of cerebral muscarinic receptors in normal human aging using positron emission tomography and [11C]tropanyl benzilate. Lee, K.S., Frey, K.A., Koeppe, R.A., Buck, A., Mulholland, G.K., Kuhl, D.E. J. Cereb. Blood Flow Metab. (1996) [Pubmed]
  24. De novo t(7;10)(q33;q23) translocation and closely juxtaposed microdeletion in a patient with macrocephaly and developmental delay. Yue, Y., Grossmann, B., Holder, S.E., Haaf, T. Hum. Genet. (2005) [Pubmed]
  25. T-cell prolymphocytic leukaemia: antigen receptor gene rearrangement and a novel mode of MTCP1 B1 activation. De Schouwer, P.J., Dyer, M.J., Brito-Babapulle, V.B., Matutes, E., Catovsky, D., Yuille, M.R. Br. J. Haematol. (2000) [Pubmed]
  26. CD4+ and CD8+ clonal T cell expansions indicate a role of antigens in ankylosing spondylitis; a study in HLA-B27+ monozygotic twins. Duchmann, R., Lambert, C., May, E., Höhler, T., Märker-Hermann, E. Clin. Exp. Immunol. (2001) [Pubmed]
  27. Characterization of the TCRB chain repertoire in the New World monkey Callithrix jacchus. Uccelli, A., Oksenberg, J.R., Jeong, M.C., Genain, C.P., Rombos, T., Jaeger, E.E., Giunti, D., Lanchbury, J.S., Hauser, S.L. J. Immunol. (1997) [Pubmed]
  28. Evidence for genetic homogeneity in autosomal recessive generalised myotonia (Becker). Koch, M.C., Ricker, K., Otto, M., Wolf, F., Zoll, B., Lorenz, C., Steinmeyer, K., Jentsch, T.J. J. Med. Genet. (1993) [Pubmed]
  29. Selective accumulation of related CD4+ T cell clones in the synovial fluid of patients with rheumatoid arthritis. Striebich, C.C., Falta, M.T., Wang, Y., Bill, J., Kotzin, B.L. J. Immunol. (1998) [Pubmed]
  30. Molecular cytogenetic detection of chromosomal breakpoints in T-cell receptor gene loci. Gesk, S., Martín-Subero, J.I., Harder, L., Luhmann, B., Schlegelberger, B., Calasanz, M.J., Grote, W., Siebert, R. Leukemia (2003) [Pubmed]
  31. Comparative sequence analysis of the human T cell receptor TCRA and TCRB CDR3 regions. Moss, P.A., Bell, J.I. Hum. Immunol. (1996) [Pubmed]
  32. Clonal proliferation of T-Cell large granular lymphocytes. Boeckx, N., Uyttebroeck, A., Langerak, A.W., Brusselmans, C., Goossens, W., Bossuyt, X. Pediatric blood & cancer. (2004) [Pubmed]
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