- Mutations of ras protooncogenes and p53 tumor suppressor gene in cardiac hemangiosarcomas from B6C3F1 mice exposed to 1,3-butadiene for 2 years. Hong, H.H., Devereux, T.R., Melnick, R.L., Moomaw, C.R., Boorman, G.A., Sills, R.C. Toxicologic pathology. (2000)