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MeSH Review


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Disease relevance of Hemangiosarcoma


High impact information on Hemangiosarcoma


Chemical compound and disease context of Hemangiosarcoma


Biological context of Hemangiosarcoma


Anatomical context of Hemangiosarcoma


Gene context of Hemangiosarcoma

  • The strong expression of KDR by tumor cells in KS and angiosarcoma implies that VPF/VEGF may also have a direct effect on tumor cells [24].
  • Tumor cells in KS and angiosarcoma strongly expressed KDR but not flt-1 mRNA [24].
  • Myr-Akt2 and Myr-Akt3 also induced hemangiosarcomas in the animal, whereas wild type Akt2 and Akt3 were not oncogenic in vivo [25].
  • Cadherin expression inversely correlates with tumor malignancy and the endothelial specific VE-cadherin is low or absent in angiosarcomas, suggesting an inhibitory role for this protein in tumor progression [26].
  • However, angiosarcomas were heterogeneous; CD31 was positive in 21/27, CD34 in 25/27 cases, BNH9 in 22/25, and vWF in 18/27 cases [27].

Analytical, diagnostic and therapeutic context of Hemangiosarcoma


  1. Vinyl-chloride-induced liver disease. From idiopathic portal hypertension (Banti's syndrome) to Angiosarcomas. Thomas, L.B., Popper, H., Berk, P.D., Selikoff, I., Falk, H. N. Engl. J. Med. (1975) [Pubmed]
  2. Differential repair of O(6)-methylguanine in DNA of rat hepatocytes and nonparenchymal cells. Lewis, J.G., Swenberg, J.A. Nature (1980) [Pubmed]
  3. Hepatic angiosarcoma and bronchioloalveolar carcinoma induced by Fowler's solution. Kasper, M.L., Schoenfield, L., Strom, R.L., Theologides, A. JAMA (1984) [Pubmed]
  4. Vinyl chloride-associated liver disease. Berk, P.D., Martin, J.F., Young, R.S., Creech, J., Selikoff, I.J., Falk, H., Watanabe, P., Popper, H., Thomas, L. Ann. Intern. Med. (1976) [Pubmed]
  5. Angiosarcoma of the liver associated with diethylstilbestrol. Hoch-Ligeti, C. JAMA (1978) [Pubmed]
  6. N-nitroso-2,6-dimethylmorpholine-induced hemangiosarcomas in the livers of randombred guinea pigs. Rao, M.S., Scarpelli, D.G., Lijinsky, W. J. Natl. Cancer Inst. (1980) [Pubmed]
  7. Effect of lifetime exposure to aflatoxin b1 in rats. Ward, J.M., Sontag, J.M., Weisburger, E.K., Brown, C.A. J. Natl. Cancer Inst. (1975) [Pubmed]
  8. Hepatic angiosarcoma associated with androgenic-anabolic steroids. Falk, H., Thomas, L.B., Popper, H., Ishak, K.G. Lancet (1979) [Pubmed]
  9. Angiosarcoma of the liver associated with Fowler's solution (potassium arsenite). Lander, J.J., Stanley, R.J., Sumner, H.W., Boswell, D.C., Aach, R.D. Gastroenterology (1975) [Pubmed]
  10. Immunosuppression in primary liver and colon tumor induction with N-hydroxy-N-2-fluorenylacetamide and azoxymethane. Kroes, R., Berkvens, J.M., Weisburger, J.H. Cancer Res. (1975) [Pubmed]
  11. Carcinogenicity of N-phenyl-1-naphthylamine and N-phenyl-2-naphthylamine in mice. Wang, H.W., Wang, D., Dzeng, R.W. Cancer Res. (1984) [Pubmed]
  12. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. Bai, X., Cerimele, F., Ushio-Fukai, M., Waqas, M., Campbell, P.M., Govindarajan, B., Der, C.J., Battle, T., Frank, D.A., Ye, K., Murad, E., Dubiel, W., Soff, G., Arbiser, J.L. J. Biol. Chem. (2003) [Pubmed]
  13. The clinical features of hepatic angiosarcoma: a report of four cases and a review of the English literature. Locker, G.Y., Doroshow, J.H., Zwelling, L.A., Chabner, B.A. Medicine (Baltimore) (1979) [Pubmed]
  14. Mutagenesis of ras proto-oncogenes in rat liver tumors induced by vinyl chloride. Froment, O., Boivin, S., Barbin, A., Bancel, B., Trepo, C., Marion, M.J. Cancer Res. (1994) [Pubmed]
  15. Inhibition of MAP kinase kinase causes morphological reversion and dissociation between soft agar growth and in vivo tumorigenesis in angiosarcoma cells. LaMontagne, K.R., Moses, M.A., Wiederschain, D., Mahajan, S., Holden, J., Ghazizadeh, H., Frank, D.A., Arbiser, J.L. Am. J. Pathol. (2000) [Pubmed]
  16. Potent inhibition of hemangiosarcoma development in mice by cidofovir. Liekens, S., Verbeken, E., De Clercq, E., Neyts, J. Int. J. Cancer (2001) [Pubmed]
  17. p16INK4A-alterations in primary angiosarcoma of the liver. Tannapfel, A., Weihrauch, M., Benicke, M., Uhlmann, D., Hauss, J., Wrbitzky, R., Wittekind, C. J. Hepatol. (2001) [Pubmed]
  18. Sporadic and Thorotrast-induced angiosarcomas of the liver manifest frequent and multiple point mutations in K-ras-2. Przygodzki, R.M., Finkelstein, S.D., Keohavong, P., Zhu, D., Bakker, A., Swalsky, P.A., Soini, Y., Ishak, K.G., Bennett, W.P. Lab. Invest. (1997) [Pubmed]
  19. Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo. Arbiser, J.L., Larsson, H., Claesson-Welsh, L., Bai, X., LaMontagne, K., Weiss, S.W., Soker, S., Flynn, E., Brown, L.F. Am. J. Pathol. (2000) [Pubmed]
  20. Expression of endomucin, a novel endothelial sialomucin, in normal and diseased human skin. Kuhn, A., Brachtendorf, G., Kurth, F., Sonntag, M., Samulowitz, U., Metze, D., Vestweber, D. J. Invest. Dermatol. (2002) [Pubmed]
  21. Primary angiosarcoma of the mediastinum: light and electron microscopic demonstration of Factor VIII-related antigen in neoplastic cells. Gibbs, A.R., Johnson, N.F., Giddings, J.C., Powell, D.E., Jasani, B. Hum. Pathol. (1984) [Pubmed]
  22. SVR angiosarcomas can be rejected by CD4 costimulation dependent and CD8 costimulation independent pathways. Arbiser, J.L., Bingaman, A., Durham, M., Cowan, S., Cohen, C., Zarnegar, E., Varma, V., Larsen, C.P. Mol. Med. (2002) [Pubmed]
  23. Angiomatoid carcinoma and 'angiosarcoma' of the thyroid gland. A spectrum of endothelial differentiation. Mills, S.E., Gaffey, M.J., Watts, J.C., Swanson, P.E., Wick, M.R., LiVolsi, V.A., Nappi, O., Weiss, L.M. Am. J. Clin. Pathol. (1994) [Pubmed]
  24. Strong expression of kinase insert domain-containing receptor, a vascular permeability factor/vascular endothelial growth factor receptor in AIDS-associated Kaposi's sarcoma and cutaneous angiosarcoma. Brown, L.F., Tognazzi, K., Dvorak, H.F., Harrist, T.J. Am. J. Pathol. (1996) [Pubmed]
  25. Oncogenic transformation induced by membrane-targeted Akt2 and Akt3. Mende, I., Malstrom, S., Tsichlis, P.N., Vogt, P.K., Aoki, M. Oncogene (2001) [Pubmed]
  26. Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications. Zanetta, L., Corada, M., Grazia Lampugnani, M., Zanetti, A., Breviario, F., Moons, L., Carmeliet, P., Pepper, M.S., Dejana, E. Thromb. Haemost. (2005) [Pubmed]
  27. Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-antigens--evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor. Miettinen, M., Lindenmayer, A.E., Chaubal, A. Mod. Pathol. (1994) [Pubmed]
  28. Hepatic angiosarcoma. Animal model: angiosarcoma of rats and mice induced by vinyl chloride. Hong, C.B., Winston, J.M., Lee, C.C. Am. J. Pathol. (1980) [Pubmed]
  29. Angiosarcoma and other vascular tumors of the breast. Donnell, R.M., Rosen, P.P., Lieberman, P.H., Kaufman, R.J., Kay, S., Braun, D.W., Kinne, D.W. Am. J. Surg. Pathol. (1981) [Pubmed]
  30. Angiosarcoma of the liver: MR imaging pre- and post-chemotherapy. Worawattanakul, S., Semelka, R.C., Kelekis, N.L., Woosley, J.T. Magnetic resonance imaging. (1997) [Pubmed]
  31. Primary cerebral angiosarcoma. Case report. Charman, H.P., Lowenstein, D.H., Cho, K.G., DeArmond, S.J., Wilson, C.B. J. Neurosurg. (1988) [Pubmed]
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