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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons.

The neuropeptide galanin colocalizes with choline acetyltransferase, the synthetic enzyme for acetylcholine, in a subset of cholinergic neurons in the basal forebrain of rodents. Chronic intracerebroventricular infusion of nerve growth factor induces a 3- to 4-fold increase in galanin gene expression in these neurons. Here we report the loss of a third of cholinergic neurons in the medial septum and vertical limb diagonal band of the basal forebrain of adult mice carrying a targeted loss-of-function mutation in the galanin gene. These deficits are associated with a 2-fold increase in the number of apoptotic cells in the forebrain at postnatal day seven. This loss is associated with marked age-dependent deficits in stimulated acetylcholine release, performance in the Morris water maze, and induction of long-term potentiation in the CA1 region of the hippocampus. These data provide unexpected evidence that galanin plays a trophic role to regulate the development and function of a subset of septohippocampal cholinergic neurons.[1]

References

  1. Galanin regulates the postnatal survival of a subset of basal forebrain cholinergic neurons. O'Meara, G., Coumis, U., Ma, S.Y., Kehr, J., Mahoney, S., Bacon, A., Allen, S.J., Holmes, F., Kahl, U., Wang, F.H., Kearns, I.R., Ove-Ogren, S., Dawbarn, D., Mufson, E.J., Davies, C., Dawson, G., Wynick, D. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
 
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