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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Phellinsin A, a novel chitin synthases inhibitor produced by Phellinus sp. PL3.

Phellinsin A, a novel chitin synthases inhibitor was isolated from the cultured broth of fungus PL3, which was identified as Phellinus sp. PL3. Phellinsin A was purified by solvent partition, silica gel, ODS column chromatographies, and preparative HPLC, consecutively. The structure of phellinsin A was assigned as a phenolic compound on the basis of various spectroscopic analyses including UV, IR, Mass, and NMR. Its molecular weight and formula were found to be 358 and C18H14O8, respectively. Phellinsin A selectively inhibited chitin synthase I and II of Saccharomyces cerevisiae with an IC50 value of 76 and 28 microg/ml, respectively, in our cell free assay system. This compound showed antifungal activity against Colletotrichum lagenarium, Pyricularia oryzae, Rhizoctonia solani, Aspergillus fumigatus, and Trichophyton mentagrophytes.[1]

References

  1. Phellinsin A, a novel chitin synthases inhibitor produced by Phellinus sp. PL3. Hwang, E.I., Yun, B.S., Kim, Y.K., Kwon, B.M., Kim, H.G., Lee, H.B., Jeong, W.J., Kim, S.U. J. Antibiot. (2000) [Pubmed]
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