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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Ehrengruber, M.U. et al.

Ehrengruber, Muhlebach, Söhrman, Leutenegger, Lester, Davidson,

Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus.

Early growth response (EGR) transcription factors link initial cytoplasmic events to long-term alterations of cellular gene expression and are induced by various stimuli. To test their roles in cell physiology, we constructed adenoviral recombinants encoding NGFI-A binding protein 2 (NAB2, a repressor of EGR1, EGR2, and EGR3), EGR1, NAB-insensitive EGR1(I293F) (EGR1*), EGR2, and the NAB-binding, repressive domain 1 (R1) of EGR1. These viruses regulated EGR-dependent expression of GFP and luciferase reporter genes in heterologous expression assays. Infection of a myoblast cell line with EGR1 and EGR1* adenovirus induced the endogenous gene for platelet-derived growth factor A chain (PDGF-A). In addition, in neuroblastoma cells, the two novel EGR1 target genes EGR3 and NAB2 were identified by using adenoviral transfer of EGR1 and EGR1*. Our results demonstrate that recombinant adenovirus is useful to regulate heterologous and endogenous EGR target gene expression, and suggest that EGR transcription factors can autoregulate themselves.[1]

References

Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus. Ehrengruber, M.U., Muhlebach, S.G., Söhrman, S., Leutenegger, C.M., Lester, H.A., Davidson, N. Gene (2000) [Pubmed]

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