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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Malonate-induced cortico-motoneuron death is attenuated by NT-4, but not by BDNF or NT-3.

Neurotrophins are promising candidates to slow the progression of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease in which spinal and cortical motoneurons selectively degenerate. In a long-term in vitro model, malonate-induced toxicity and cell death of motoneurons have been demonstrated. Here we studied the neuroprotective effect of BDNF, NT-3, and NT-4 on the cell death of cortical motoneurons in an organotypic culture model after chronic mitochondrial inhibition with malonate. Our data show that NT-4 completely prevents malonate-induced toxicity, whereas BDNF or NT-3 had no neuroprotective effect. In clinical trials for ALS, predominantly focussed on the survival of spinal motoneurons, BDNF has already been tested with disappointing results; our results suggest that NT-4 may be a better neurotrophin to prevent motoneuron loss.[1]

References

  1. Malonate-induced cortico-motoneuron death is attenuated by NT-4, but not by BDNF or NT-3. Van Westerlaak, M.G., Bär, P.R., Cools, A.R., Joosten, E.A. Neuroreport (2001) [Pubmed]
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