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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

TGF-beta is a critical mediator of acute lung injury.

We have shown that the integrin alphavbeta6 activates latent TGF-beta in the lungs and skin. We show here that mice lacking this integrin are completely protected from pulmonary edema in a model of bleomycin-induced acute lung injury (ALI). Pharmacologic inhibition of TGF-beta also protected wild-type mice from pulmonary edema induced by bleomycin or Escherichia coli endotoxin. TGF-beta directly increased alveolar epithelial permeability in vitro by a mechanism that involved depletion of intracellular glutathione. These data suggest that integrin-mediated local activation of TGF-beta is critical to the development of pulmonary edema in ALI and that blocking TGF-beta or its activation could be effective treatments for this currently untreatable disorder.[1]


  1. TGF-beta is a critical mediator of acute lung injury. Pittet, J.F., Griffiths, M.J., Geiser, T., Kaminski, N., Dalton, S.L., Huang, X., Brown, L.A., Gotwals, P.J., Koteliansky, V.E., Matthay, M.A., Sheppard, D. J. Clin. Invest. (2001) [Pubmed]
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