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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Human umbilical cord blood cells ameliorate Alzheimer's disease in transgenic mice.

Having had success in extending the life of mice with a transgene for amyotropic lateral sclerosis (SOD1) mice and Huntington's disease (Hdexon1), we administered megadoses of human umbilical cord blood mononuclear cells to mice with Alzheimer's disease. These mice have an over-expression of human Alzheimer amyloid precursor protein (APP), die early and develop a CNS disorder that includes neophobia. When given 110 x 10(6) human umbilical cord blood mononuclear cells, these mice (HuAPP 695.SWE) had considerable extension of life with a p value of 0.001 when compared to control animals.[1]

References

  1. Human umbilical cord blood cells ameliorate Alzheimer's disease in transgenic mice. Ende, N., Chen, R., Ende-Harris, D. Journal of medicine. (2001) [Pubmed]
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