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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Apoptosis induced by picolinic acid-related compounds in HL-60 cells.

We have found that niacin-related compounds, particularly picolinic acid, induced apoptosis in human leukemia cells. In this paper, we investigated whether various picolinic acid-related compounds had apoptosis-inducing activities or not. Particularly, fusaric acid, picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also induced apoptosis in HL-60 cells. These results suggest that pyridine substituted with various groups and the consequent change of resonance structure may have an important role in the induction of apoptosis.[1]


  1. Apoptosis induced by picolinic acid-related compounds in HL-60 cells. Ogata, S., Inoue, K., Iwata, K., Okumura, K., Taguchi, H. Biosci. Biotechnol. Biochem. (2001) [Pubmed]
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