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Chemical Compound Review

Picolinal     pyridine-2-carbaldehyde

Synonyms: PubChem11741, CHEMBL274794, NSC-8951, ACMC-1BNOZ, P62003_ALDRICH, ...
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Disease relevance of picolinaldehyde


High impact information on picolinaldehyde


Chemical compound and disease context of picolinaldehyde


Anatomical context of picolinaldehyde


Associations of picolinaldehyde with other chemical compounds


Gene context of picolinaldehyde

  • AR and HDH isozymes reduce the aromatic substrate, PCA, and thus have the general characteristics of an aldehyde reductase [14].

Analytical, diagnostic and therapeutic context of picolinaldehyde


  1. Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. Liu, M.C., Lin, T.S., Sartorelli, A.C. J. Med. Chem. (1992) [Pubmed]
  2. Inhibition of tumor cell transplantability by iron and copper complexes of 5-substituted 2-formylpyridine thiosemicarbazones. Antholine, W.E., Knight, J.M., Petering, D.H. J. Med. Chem. (1976) [Pubmed]
  3. Antineoplastic and biochemical properties of arylsulfonylhydrazones of 2-formylpyridine N-oxide. Sartorelli, A.C., Agrawal, K.C., Booth, B.A., Pittman, J., Bartholomew, D.G. J. Med. Chem. (1976) [Pubmed]
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  5. Environment-selective synergism using self-assembling cytotoxic and antimicrobial agents. Rideout, D., Jaworski, J., Dagnino, R. Biochem. Pharmacol. (1988) [Pubmed]
  6. Synthesis and biological activity of 3- and 5-amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone. Liu, M.C., Lin, T.S., Cory, J.G., Cory, A.H., Sartorelli, A.C. J. Med. Chem. (1996) [Pubmed]
  7. Synthesis and characterization of highly conjugated, chiral bridging ligands. Sauers, A.L., Ho, D.M., Bernhard, S. J. Org. Chem. (2004) [Pubmed]
  8. Chloroform-soluble schiff-base Zn(II) or Cd(II) complexes from a dynamic combinatorial library. Epstein, D.M., Choudhary, S., Churchill, M.R., Keil, K.M., Eliseev, A.V., Morrow, J.R. Inorganic chemistry. (2001) [Pubmed]
  9. Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo. Cory, J.G., Cory, A.H., Rappa, G., Lorico, A., Liu, M.C., Lin, T.S., Sartorelli, A.C. Adv. Enzyme Regul. (1995) [Pubmed]
  10. Inhibition of iron uptake in HL60 cells by 2-formylpyridine monothiosemicarbazonato Cu(II). Narasimhan, J., Antholine, W.E., Chitambar, C.R., Petering, D.H. Arch. Biochem. Biophys. (1991) [Pubmed]
  11. S-methyldithiocarbazate and its Schiff bases: evaluation of bondings and biological properties. Tarafder, M.T., Kasbollah, A., Saravanan, N., Crouse, K.A., Ali, A.M., Tin Oo, K. J. Biochem. Mol. Biol. Biophys. (2002) [Pubmed]
  12. Effects of 2-formylpyridine monothiosemicarbazonato copper II on red cell components. Antholine, W.E., Taketa, F. J. Inorg. Biochem. (1984) [Pubmed]
  13. Antiviral activity of platinum (II) and palladium (II) complexes of pyridine-2-carbaldehyde thiosemicarbazone. Varadinova, T., Kovala-Demertzi, D., Rupelieva, M., Demertzis, M., Genova, P. Acta Virol. (2001) [Pubmed]
  14. Tissue distribution of mammalian aldose reductase and related enzymes. Markus, H.B., Raducha, M., Harris, H. Biochemical medicine. (1983) [Pubmed]
  15. Development of novel aroylhydrazone ligands for iron chelation therapy: 2-pyridylcarboxaldehyde isonicotinoyl hydrazone analogs. Becker, E., Richardson, D.R. J. Lab. Clin. Med. (1999) [Pubmed]
  16. Molybdenum carbonyl complexes with pyridylimino acidato ligands. García-Rodríguez, R., Miguel, D. Dalton transactions (Cambridge, England : 2003) (2006) [Pubmed]
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