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Chemical Compound Review

wampocap     pyridine-3-carboxylic acid

Synonyms: Enduracin, Induracin, nicamin, nicobid, nicocap, ...
 
 
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Disease relevance of nicotinic acid

  • Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial [1].
  • Bionic epidural stimulation restores arterial pressure regulation during orthostasis [2].
  • Although remodeling may constrain therapeutic intervals for molecular, cellular, or bionic rescue, the exposure of intrinsic retinal remodeling by the removal of sensory control in retinal degenerations suggests that neuronal organization in the normal retina may be more plastic than previously believed [3].
  • Evaluation of the efficacy and tolerability of oral terbinafine (Daskil) in patients with seborrhoeic dermatitis. A multicentre, randomized, investigator-blinded, placebo-controlled trial [4].
  • The bionic glove: an electrical stimulator garment that provides controlled grasp and hand opening in quadriplegia [5].
  • New drugs acting via the nicotinic acid receptor or related receptors, as well as new co-medications that suppress unwanted effects of nicotinic acid, will most likely be introduced as new therapeutic options in the treatment of dyslipidemia and the prevention of cardiovascular diseases [6].
 

Psychiatry related information on nicotinic acid

  • OBJECTIVE: This study compared speech perception benefits in adults implanted with the HiResolution (HiRes) Bionic Ear who used both conventional and HiRes sound processing [7].
  • The group psychotherapist as contemporary mystic: a bionic object relations perspective [8].
 

High impact information on nicotinic acid

  • Two hundred one male and female subjects, aged 20 to 70 years, with elevated low-density lipoprotein cholesterol values (in the 75th to 95th percentiles), participated in a randomized, controlled, double-blind study using a new form of niacin (Enduracin), which employs a wax-matrix vehicle for sustained release [9].
  • Muscle glycogenolysis was 15.3 +/- 9.6% greater in the NA trial vs. the CON trial but did not reach statistical significance [10].
  • A bionic baroreflex system (BBS) is a computer-assisted intelligent feedback system to control arterial pressure (AP) for the treatment of baroreflex failure [2].
  • STUDY DESIGN: A repeated-measures design was used to assess postimplantation speech perception in adults who received the HiResolution Bionic Ear in a recent clinical trial [7].
  • Safety and effectiveness of Niaspan when added sequentially to a statin for treatment of dyslipidemia [11].
 

Chemical compound and disease context of nicotinic acid

 

Biological context of nicotinic acid

  • We will review recent evidence bearing on autonomic tone in MSA and discuss their therapeutic implications, particularly in terms of the possible development of a bionic baroreflex for better control of blood pressure [15].
  • All major manufacturers of multichannel implant systems, including Advanced Bionics Corp., Bionic Systems, Cochlear Pty [16].
  • Bionic, organic, and hybrid spare parts in clinical medicine [17].
 

Anatomical context of nicotinic acid

  • Moreover, in contrast to sustained-release formulations, Niaspan showed relatively mild hepatic effects [12].
  • The adhesion of neuronal cells accompanied by neurite outgrowth indicates that the system might provide a functional interface between the neuromuscular system and an electromagnetic material that could be useful in bionic engineering [18].
  • CONCLUSION: The Bionic Glove can significantly improve independence in people with C5-C7 spinal cord injury if their initial Functional Independence Measure and Quadriplegia Index of Function scores are 20% to 50% of the maximum values [19].
  • A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems [20].
  • RESULTS: At concentration of 10 mM, NA could not enhance the proliferation of mature hepatocytes but induced the appearance of small hepatocyte colonies [21].
 

Associations of nicotinic acid with other chemical compounds

 

Gene context of nicotinic acid

  • INTERVENTION: Eight weeks of diet alone (American Heart Association Step I Diet) was followed by randomization to 2 treatment groups (1500 mg/d CNA [ENDURACIN] or placebo) for 2 months followed by a crossover of treatments for 2 months, followed by all subjects taking 2000 mg/d of CNA for 2 months [26].
  • BACKGROUND: We proposed a novel therapeutic strategy against central baroreflex failure: implementation of an artificial baroreflex system to automatically regulate sympathetic vasomotor tone, ie, a bionic baroreflex system (BBS), and we tested its efficacy in a model of sudden hypotension during surgery [27].
 

Analytical, diagnostic and therapeutic context of nicotinic acid

  • PURPOSE: To determine the response of cochlear implants ("bionic ears") to therapeutic irradiation [28].
  • Over the past 50 years, we have made remarkable advances in the use of bionic devices and solid organ transplants as replacement parts for failing tissues and organs [29].
  • Coffee creamer, the bionic man, and organ preservation [30].
  • Biodegradable implants have allowed a paradigm shift away from bionic (mechanical replacement) engineering and toward true biologic solutions to reconstructive problems in arthroscopic surgery [31].
  • Considerable scientific and technological efforts have been devoted to develop neuroprostheses and hybrid bionic systems that link the human nervous system with electronic or robotic prostheses, with the main aim of restoring motor and sensory functions in disabled patients [20].

References

  1. Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes: results of the assessment of diabetes control and evaluation of the efficacy of niaspan trial. Grundy, S.M., Vega, G.L., McGovern, M.E., Tulloch, B.R., Kendall, D.M., Fitz-Patrick, D., Ganda, O.P., Rosenson, R.S., Buse, J.B., Robertson, D.D., Sheehan, J.P. Arch. Intern. Med. (2002) [Pubmed]
  2. Bionic epidural stimulation restores arterial pressure regulation during orthostasis. Yanagiya, Y., Sato, T., Kawada, T., Inagaki, M., Tatewaki, T., Zheng, C., Kamiya, A., Takaki, H., Sugimachi, M., Sunagawa, K. J. Appl. Physiol. (2004) [Pubmed]
  3. Retinal remodeling in inherited photoreceptor degenerations. Marc, R.E., Jones, B.W. Mol. Neurobiol. (2003) [Pubmed]
  4. Evaluation of the efficacy and tolerability of oral terbinafine (Daskil) in patients with seborrhoeic dermatitis. A multicentre, randomized, investigator-blinded, placebo-controlled trial. Scaparro, E., Quadri, G., Virno, G., Orifici, C., Milani, M. Br. J. Dermatol. (2001) [Pubmed]
  5. The bionic glove: an electrical stimulator garment that provides controlled grasp and hand opening in quadriplegia. Prochazka, A., Gauthier, M., Wieler, M., Kenwell, Z. Archives of physical medicine and rehabilitation. (1997) [Pubmed]
  6. Nicotinic acid: pharmacological effects and mechanisms of action. Gille, A., Bodor, E.T., Ahmed, K., Offermanns, S. Annu. Rev. Pharmacol. Toxicol. (2008) [Pubmed]
  7. HiResolution and conventional sound processing in the HiResolution bionic ear: using appropriate outcome measures to assess speech recognition ability. Koch, D.B., Osberger, M.J., Segel, P., Kessler, D. Audiol. Neurootol. (2004) [Pubmed]
  8. The group psychotherapist as contemporary mystic: a bionic object relations perspective. Schermer, V.L. International journal of group psychotherapy. (2001) [Pubmed]
  9. Niacin revisited. A randomized, controlled trial of wax-matrix sustained-release niacin in hypercholesterolemia. Keenan, J.M., Fontaine, P.L., Wenz, J.B., Myers, S., Huang, Z.Q., Ripsin, C.M. Arch. Intern. Med. (1991) [Pubmed]
  10. Effects of reduced free fatty acid availability on skeletal muscle PDH activation during aerobic exercise. Pyruvate dehydrogenase. Stellingwerff, T., Watt, M.J., Heigenhauser, G.J., Spriet, L.L. Am. J. Physiol. Endocrinol. Metab. (2003) [Pubmed]
  11. Safety and effectiveness of Niaspan when added sequentially to a statin for treatment of dyslipidemia. Wolfe, M.L., Vartanian, S.F., Ross, J.L., Bansavich, L.L., Mohler, E.R., Meagher, E., Friedrich, C.A., Rader, D.J. Am. J. Cardiol. (2001) [Pubmed]
  12. A new extended-release niacin (Niaspan): efficacy, tolerability, and safety in hypercholesterolemic patients. Morgan, J.M., Capuzzi, D.M., Guyton, J.R. Am. J. Cardiol. (1998) [Pubmed]
  13. Lowering plasma free fatty acid levels improves insulin action in conscious pregnant rabbits. Gilbert, M., Basile, S., Baudelin, A., Pere, M.C. Am. J. Physiol. (1993) [Pubmed]
  14. Total peroxyl radical-trapping ability and anti-oxidant vitamins of the umbilical venous plasma and the placenta in pre-eclampsia. Kim, Y.H., Kim, C.H., Cho, M.K., Kim, K.M., Lee, S.Y., Ahn, B.W., Yang, S.Y., Kim, S.M., Song, T.B. J. Obstet. Gynaecol. Res. (2006) [Pubmed]
  15. The nature of the autonomic dysfunction in multiple system atrophy. Parikh, S.M., Diedrich, A., Biaggioni, I., Robertson, D. J. Neurol. Sci. (2002) [Pubmed]
  16. The future of cochlear implants. Wilson, B.S. British journal of audiology. (1997) [Pubmed]
  17. Bionic, organic, and hybrid spare parts in clinical medicine. Friedman, E.A. Transplant. Proc. (1980) [Pubmed]
  18. Cell growth on metallic glasses: the interaction of amorphous metal alloys with cultured neuronal, osteoblast, endothelial, and fibroblast cells. McAuslan, B.R., Johnson, G., Delamore, G.W., Gibson, M.A., Steele, J.G. J. Biomed. Mater. Res. (1988) [Pubmed]
  19. Clinical evaluation of the bionic glove. Popović, D., Stojanović, A., Pjanović, A., Radosavljević, S., Popović, M., Jović, S., Vulović, D. Archives of physical medicine and rehabilitation. (1999) [Pubmed]
  20. A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems. Navarro, X., Krueger, T.B., Lago, N., Micera, S., Stieglitz, T., Dario, P. J. Peripher. Nerv. Syst. (2005) [Pubmed]
  21. Effects of nicotinamide-related agents on the growth of primary rat hepatocytes and formation of small hepatocyte colonies. Sato, F., Mitaka, T., Mizuguchi, T., Mochizuki, Y., Hirata, K. Liver (1999) [Pubmed]
  22. Dissolution profiles of nonprescription extended-release niacin and inositol niacinate products. Poon, I.O., Chow, D.S., Liang, D. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. (2006) [Pubmed]
  23. Assay of nicotinamide deamidase activity using high-performance liquid chromatography. Oishi, M., Ogasawara, Y., Ishii, K., Tanabe, S. J. Chromatogr. B Biomed. Sci. Appl. (1998) [Pubmed]
  24. Growth hormone response to thyrotropin releasing hormone in a pellagrin. Ieiri, T., Kuroda, H., Shimoda, S. Endocrinol. Jpn. (1984) [Pubmed]
  25. Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1. Lai, E., De Lepeleire, I., Crumley, T.M., Liu, F., Wenning, L.A., Michiels, N., Vets, E., O'Neill, G., Wagner, J.A., Gottesdiener, K. Clin. Pharmacol. Ther. (2007) [Pubmed]
  26. Clinical trial of wax-matrix sustained-release niacin in a Russian population with hypercholesterolemia. Aronov, D.M., Keenan, J.M., Akhmedzhanov, N.M., Perova, N.V., Oganov, R.Y., Kiseleva, N.Y. Archives of family medicine. (1996) [Pubmed]
  27. Artificial baroreflex: clinical application of a bionic baroreflex system. Yamasaki, F., Ushida, T., Yokoyama, T., Ando, M., Yamashita, K., Sato, T. Circulation (2006) [Pubmed]
  28. Cochlear implants: response to therapeutic irradiation. Ralston, A., Stevens, G., Mahomudally, E., Ibrahim, I., Leckie, E. Int. J. Radiat. Oncol. Biol. Phys. (1999) [Pubmed]
  29. Regenerative biology and engineering: strategies for tissue restoration. Stocum, D.L. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. (1998) [Pubmed]
  30. Coffee creamer, the bionic man, and organ preservation. Southard, J.H. Surgery (2002) [Pubmed]
  31. The evolution of clinical applications of biodegradable implants in arthroscopic surgery. Burkhart, S.S. Biomaterials (2000) [Pubmed]
 
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