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Chemical Compound Review

fusaric acid     5-butylpyridine-2-carboxylic acid

Synonyms: Prestwick_233, Lopac-F-6513, Fusarinic acid, CHEMBL24510, SureCN178006, ...
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Disease relevance of fusaric acid


Psychiatry related information on fusaric acid


High impact information on fusaric acid


Chemical compound and disease context of fusaric acid


Biological context of fusaric acid


Anatomical context of fusaric acid


Associations of fusaric acid with other chemical compounds


Gene context of fusaric acid

  • The stimulatory feedback effect of EB on prolactin release was studied in the same animals. alpha-MT and EB produced additive effects on plasma prolactin levels whereas fusaric acid blocked the EB-induced increase in plasma prolactin levels [30].
  • Fusaric acid induces apoptosis in saffron root-tip cells: roles of caspase-like activity, cytochrome c, and H(2)O (2) [18].
  • The effect of single agent oral fusaric acid (FA) on the growth of subcutaneously xenografted SCC-1 cells in a nude mouse model [31].
  • Other inhibitors of DBH, e.g. fusaric acid and diethyldithiocarbaminate (DDC), did not interfere with DA uptake [32].
  • Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick [7].

Analytical, diagnostic and therapeutic context of fusaric acid


  1. Suppression of elevated serum TSH levels in hypothyroidism by fusaric acid. Yoshimura, M., Hachiya, T., Ochi, Y., Nagasaka, A., Takeda, A. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  2. Characterization and protective properties of attenuated mutants of Salmonella choleraesuis. Kelly, S.M., Bosecker, B.A., Curtiss, R. Infect. Immun. (1992) [Pubmed]
  3. Role of chemotaxis toward fusaric acid in colonization of hyphae of Fusarium oxysporum f. sp. radicis-lycopersici by Pseudomonas fluorescens WCS365. de Weert, S., Kuiper, I., Lagendijk, E.L., Lamers, G.E., Lugtenberg, B.J. Mol. Plant Microbe Interact. (2004) [Pubmed]
  4. Production of fusaric acid by Fusarium species. Bacon, C.W., Porter, J.K., Norred, W.P., Leslie, J.F. Appl. Environ. Microbiol. (1996) [Pubmed]
  5. Genome rearrangements by residual IS10 elements in strains of Escherichia coli K-12 which had undergone Tn10 mutagenesis and fusaric acid selection. Bogosian, G., Bilyeu, K., O'Neil, J.P. Gene (1993) [Pubmed]
  6. Effect of fusaric acid on aggression, motor activity, and brain monoamines in mice. Diringer, M.N., Kramarcy, N.R., Brown, J.W., Thurmond, J.B. Pharmacol. Biochem. Behav. (1982) [Pubmed]
  7. Intracerebroventricular injection of fusaric acid attenuates the anorexia by glucagon-like peptide-1 in the neonatal chick. Bungo, T., Kawakami, S.I., Ohgushi, A., Sashihara, K., Saito, N., Sugahara, K., Hasegawa, S., Denbow, D.M., Furuse, M. Pharmacol. Biochem. Behav. (2001) [Pubmed]
  8. Suppression of craving and withdrawal in humans addicted to narcotics or amphetamines by administration of alpha-methyl-para-tyrosine (AMPT) and 5-butylpicolinic acid (fusaric acid) treatment of narcotic and amphetamine addiction in humans: preliminary report. Pozuels, J. Cleveland Clinic quarterly. (1976) [Pubmed]
  9. Modification of cerebrovascular CO2 reactivity by inhibition of dopamine beta-hydroxylase. Oishi, M., Gotoh, F., Toyoda, M., Seki, T., Takeoka, T., Takagi, S., Niimi, T. Stroke (1979) [Pubmed]
  10. Expression of human dopamine beta-hydroxylase in Drosophila Schneider 2 cells. Li, B., Tsing, S., Kosaka, A.H., Nguyen, B., Osen, E.G., Bach, C., Chan, H., Barnett, J. Biochem. J. (1996) [Pubmed]
  11. Changes of neuropeptide Y messenger RNA and peptide by drugs influencing endogenous norepinephrine content in cerebrocortex of the rat. Niu, C.S., Chang, T.K., Cheng, J.T. J. Neurochem. (1996) [Pubmed]
  12. Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immunogenic. Curtiss, R., Kelly, S.M. Infect. Immun. (1987) [Pubmed]
  13. Fusaric acid-producing strains of Fusarium oxysporum alter 2,4-diacetylphloroglucinol biosynthetic gene expression in Pseudomonas fluorescens CHA0 in vitro and in the rhizosphere of wheat. Notz, R., Maurhofer, M., Dubach, H., Haas, D., Défago, G. Appl. Environ. Microbiol. (2002) [Pubmed]
  14. Influence of fusaric acid on phenazine-1-carboxamide synthesis and gene expression of Pseudomonas chlororaphis strain PCL1391. van Rij, E.T., Girard, G., Lugtenberg, B.J., Bloemberg, G.V. Microbiology (Reading, Engl.) (2005) [Pubmed]
  15. Enhanced growth inhibition of squamous cell carcinoma of the head and neck by combination therapy of fusaric acid and paclitaxel or carboplatin. Jaglowski, J.R., Stack, B.C. Cancer Lett. (2006) [Pubmed]
  16. Tachycardia in spontaneously hypertensive and normotensive rats after fusaric acid and bupicamide. Antonaccio, M.J., Coté, D., Cavaliere, T. Clin. Exp. Pharmacol. Physiol. (1976) [Pubmed]
  17. A putative role for fusaric acid in biocontrol of the parasitic angiosperm Orobanche ramosa. Bouizgarne, B., El-Maarouf-Bouteau, H., Madiona, K., Biligui, B., Monestiez, M., Pennarun, A.M., Amiar, Z., Rona, J.P., Ouhdouch, Y., El Hadrami, I., Bouteau, F. Mol. Plant Microbe Interact. (2006) [Pubmed]
  18. Fusaric acid induces apoptosis in saffron root-tip cells: roles of caspase-like activity, cytochrome c, and H(2)O (2). Samadi, L., Shahsavan Behboodi, B. Planta (2006) [Pubmed]
  19. Molecular cloning with bifunctional plasmid vectors in Bacillus subtilis. I. Construction and analysis of B. subtilis clone banks in Escherichia coli. Ostroff, G.R., Pène, J.J. Mol. Gen. Genet. (1984) [Pubmed]
  20. Rapid GLC determination of fusaric acid in biological fluids. Fung, K.K., Koda, R.T., Maronde, R.F., Cohen, J.L. Journal of pharmaceutical sciences. (1976) [Pubmed]
  21. Relaxation of isolated rabbit arteries by fusaric (5-butylpicolinic) acid. Hidaka, H., Asano, M. J. Pharmacol. Exp. Ther. (1976) [Pubmed]
  22. Inhibition of LH and prolactin release in the cycling rat following inhibition of dopamine-beta-hydroxylase. Voogt, J.L., Carr, L.A. Brain Res. (1981) [Pubmed]
  23. Fusaric acid-induced elevation of homovanillic acid in the CSF as an index of brain noradrenaline synthesis. Elghozi, J.L., Laude, D., Chaouloff, F. Eur. J. Pharmacol. (1985) [Pubmed]
  24. Cytotoxic activity of fusaric acid on human adenocarcinoma cells in tissue culture. Fernandez-Pol, J.A., Klos, D.J., Hamilton, P.D. Anticancer Res. (1993) [Pubmed]
  25. Contractile responses of mammalian cerebral arteries to 15-hydroperoxyarachidonic acid vary in the presence of fusaric acid and verapamil. Asano, M., Matsuda, T., Suzuki, Y., Hidaka, H. Pharmacology (1984) [Pubmed]
  26. Autoinduction of 2,4-diacetylphloroglucinol biosynthesis in the biocontrol agent Pseudomonas fluorescens CHA0 and repression by the bacterial metabolites salicylate and pyoluteorin. Schnider-Keel, U., Seematter, A., Maurhofer, M., Blumer, C., Duffy, B., Gigot-Bonnefoy, C., Reimmann, C., Notz, R., Défago, G., Haas, D., Keel, C. J. Bacteriol. (2000) [Pubmed]
  27. Construction of delta aroA his delta pur strains of Salmonella typhi. Edwards, M.F., Stocker, B.A. J. Bacteriol. (1988) [Pubmed]
  28. Dopamine, as well as norepinephrine, is a link between noradrenergic nerve terminals and splenocytes. Bencsics, A., Sershen, H., Baranyi, M., Hashim, A., Lajtha, A., Vizi, E.S. Brain Res. (1997) [Pubmed]
  29. Inhibition of dopamine beta-hydroxylase in blood vessels by picolinic acid derivatives in vivo and their anthypertensive effects. Hidaka, H., Shoka, F., Hashizume, Y., Takemoto, N., Yamamoto, M. Jpn. J. Pharmacol. (1975) [Pubmed]
  30. Catecholamine mechanisms in the feedback effects of estradiol benzoate on the release of LH and prolactin. Tobias, H., Carr, L.A., Voogt, J.L. Proc. Soc. Exp. Biol. Med. (1983) [Pubmed]
  31. The effect of single agent oral fusaric acid (FA) on the growth of subcutaneously xenografted SCC-1 cells in a nude mouse model. Ruda, J.M., Beus, K.S., Hollenbeak, C.S., Wilson, R.P., Stack, B.C. Investigational new drugs. (2006) [Pubmed]
  32. Interference of inhibitors of dopamine-beta-hydroxylase with uptake of monoamines by chromaffin granular membranes. Schlichter, D., Da Prada, M., Pletscher, A. Eur. J. Pharmacol. (1975) [Pubmed]
  33. Electrocortical changes induced by the perfusion of noradrenaline, acetylcholine and their antagonists directly into the dorsal raphé nucleus of the cat. Key, B.J., Krzywoskinski, L. Br. J. Pharmacol. (1977) [Pubmed]
  34. Morphological mutants of Gibberella fujikuroi for enhanced production of gibberellic acid. Lale, G., Jogdand, V.V., Gadre, R.V. J. Appl. Microbiol. (2006) [Pubmed]
  35. The effect of interference in catecholamine biosynthesis on captivity-induced jumping stereotypy in bank voles (Clethrionomys glareolus). Odberg, F.O., Kennes, D., De Rycke, P.H., Bouquet, Y. Archives internationales de pharmacodynamie et de thérapie. (1987) [Pubmed]
  36. Molecular cloning and characterization of the fusaric acid-resistance gene from Pseudomonas cepacia. Utsumi, R., Yagi, T., Katayama, S., Katsuragi, K., Tachibana, K., Toyoda, H., Ouchi, S., Obata, K., Shibano, Y., Noda, M. Agric. Biol. Chem. (1991) [Pubmed]
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