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Chemical Compound Review:

Rowalind pyridine-3-carbaldehyde

Synonyms: PubChem1124, zlchem 291, CHEMBL268493, CPD-9060, NSC-8952, ...

Kaplan, D., Morjana, N.A. et al., Sakamoto, M. et al., Ogata, S. et al.

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Disease relevance of nicotinaldehyde

Minimum bactericidal concentrations of salicylate, nicotinaldehyde singly, and in combination with nicotinic acid, or nicotinamide were determined for Staphylococcus aureus 79 and 80, and Escherichia coli 95, at inocula of 10(7)--10(2) [1].

High impact information on nicotinaldehyde

The best substrates for ALR2 are aromatic aldehydes (e.g. pyridine-3-aldehyde; Km = 9 microM; kcat/Km = 150,000 s-1 M-1), while among aldoses DL-glyceraldehyde is the preferred substrate (Km = 72 microM; kcat/Km = 17,250) [2].
The induction of ODC activity by DEN was inhibited by 74.3, 85.5, 94.6, 97.6, 72.6 and 55.2% by nicotinamide, nicotinic acid, 3-hydroxymethylpyridine, beta-picoline, pyridine-3-aldehyde and ethylnicotinate respectively [3].
Particularly, fusaric acid, picolinaldehyde, nicotinaldehyde, 2-aminopyridine, and 3-aminopyridine also induced apoptosis in HL-60 cells [4].

References

The sensitivity of Staphylococcus aureus 79 and 80, and Escherichia coli 95 to sodium salicylate, nicotinaldehyde singly, and in combination with nicotinic acid or nicotinamide. Kaplan, D. Chemotherapy. (1979) [Pubmed]
Aldose reductase from human psoas muscle. Purification, substrate specificity, immunological characterization, and effect of drugs and inhibitors. Morjana, N.A., Flynn, T.G. J. Biol. Chem. (1989) [Pubmed]
Inhibitory effects of niacin and its analogues on induction of ornithine decarboxylase activity by diethylnitrosamine in rat liver. Sakamoto, M., Yanagi, S., Kamiya, T. Biochem. Pharmacol. (1987) [Pubmed]
Apoptosis induced by picolinic acid-related compounds in HL-60 cells. Ogata, S., Inoue, K., Iwata, K., Okumura, K., Taguchi, H. Biosci. Biotechnol. Biochem. (2001) [Pubmed]

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