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Zammit, D.J. et al.

Zammit, Berzins, Gill, Randle-Barrett, Barnett, Koentgen, Lambert, Harvey, Boyd, Classon,

Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland.

Thymic shared antigen 1 ( TSA-1) is a plasma membrane protein of the Ly-6 superfamily expressed on thymocytes, thymic stromal cells, and other cells of the hematopoietic system. TSA-1 is also expressed in other nonhematopoietic tissues, in particular, embryonic and adult adrenal glands. To address the function of TSA-1, we generated mutant mice in which TSA-1 expression was inactivated by gene targeting. Here we show that deletion of both TSA-1 alleles results in abnormal adrenal gland development and midgestational lethality due to cardiac abnormalities. We also report that TSA-1-deficient adrenal glands have significantly reduced levels of the catecholamines noradrenaline and adrenaline. We conclude that TSA-1 is required for normal embryonic development but that deletion of its expression does not obviously impair lymphoid development.[1]

References

Essential role for the lymphostromal plasma membrane Ly-6 superfamily molecule thymic shared antigen 1 in development of the embryonic adrenal gland. Zammit, D.J., Berzins, S.P., Gill, J.W., Randle-Barrett, E.S., Barnett, L., Koentgen, F., Lambert, G.W., Harvey, R.P., Boyd, R.L., Classon, B.J. Mol. Cell. Biol. (2002) [Pubmed]

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