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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction.

Grb-2-related adaptor protein (Grap) is a Grb2-like SH3-SH2-SH3 adaptor protein with expression restricted to lymphoid tissues. Grap(-/-) lymphocytes isolated from targeted Grap-deficient mice exhibited enhanced proliferation, interleukin-2 production, and c-fos induction in response to mitogenic T-cell receptor (TCR) stimulation, compared to wild-type cells. Ectopic expression of Grap led to a suppression of Elk-1-directed transcription induced by the Ras/Erk pathway, without having effects on gene expression mediated by Jnk and p38 mitogen-activated protein kinases. Together, these data suggest that Grap, unlike Grb2, acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk pathway.[1]

References

  1. Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Shen, R., Ouyang, Y.B., Qu, C.K., Alonso, A., Sperzel, L., Mustelin, T., Kaplan, M.H., Feng, G.S. Mol. Cell. Biol. (2002) [Pubmed]
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