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Gene Review

Grap  -  GRB2-related adaptor protein

Mus musculus

Synonyms: 8430435N19Rik, BB233594, GRB2-related adapter protein
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Disease relevance of Grap


High impact information on Grap


Biological context of Grap


Anatomical context of Grap


Other interactions of Grap

  • This motif functions as a docking site for the SH2 domain-containing adapters Grb2 and Grap [3].


  1. Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome. Shiraiwa, H., Takei, M., Yoshikawa, T., Azuma, T., Kato, M., Mitamura, K., Ueki, T., Kida, A., Horie, T., Seki, N., Sawada, S. J. Int. Med. Res. (2004) [Pubmed]
  2. Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Shen, R., Ouyang, Y.B., Qu, C.K., Alonso, A., Sperzel, L., Mustelin, T., Kaplan, M.H., Feng, G.S. Mol. Cell. Biol. (2002) [Pubmed]
  3. Two distinct tyrosine-based motifs enable the inhibitory receptor FcgammaRIIB to cooperatively recruit the inositol phosphatases SHIP1/2 and the adapters Grb2/Grap. Isnardi, I., Lesourne, R., Bruhns, P., Fridman, W.H., Cambier, J.C., Daëron, M. J. Biol. Chem. (2004) [Pubmed]
  4. GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28. Ellis, J.H., Ashman, C., Burden, M.N., Kilpatrick, K.E., Morse, M.A., Hamblin, P.A. J. Immunol. (2000) [Pubmed]
  5. The adaptor protein Gads (Grb2-related adaptor downstream of Shc) is implicated in coupling hemopoietic progenitor kinase-1 to the activated TCR. Liu, S.K., Smith, C.A., Arnold, R., Kiefer, F., McGlade, C.J. J. Immunol. (2000) [Pubmed]
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