Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Tabata, M.J. et al.

Tabata, Fujii, Liu, Ohmori, Abe, Wakisaka, Iwamoto, Kurisu,

Bone morphogenetic protein 4 is involved in cusp formation in molar tooth germ of mice.

In order to clarify the role of BMP4 in the development of the tooth crown, we employed the antisense technique on molar tooth germs removed from the mandibles of embryonic 13.5-d-old mice. In the tooth germ explants incubated for 14 d with antisense oligodeoxynucleotide (AS-ODN) against Bmp4 (a) cusps were not formed, whereas dentin matrix was secreted in the whole region of the crown, (b) inner enamel epithelial (IEE) cells remained in the undifferentiated state in the occlusal region of the crown, though they differentiated in the proximal region (lateral surface region of tooth crown), and (c) insufficient growth of the dental papilla was observed. A 5-bromo-2'-deoxyuridine (BrdU) uptake experiment showed that, although a site-specific proliferation of IEE cells occurred in the occlusal region in the control explants, it was not found in the AS-ODN-treated explants. In the proximal region, however, the proliferation of IEE cells was detected evenly in all explants treated with or without AS-ODNs. These results suggest that AS-ODN against Bmp4 inhibited the differentiation and the site-specific proliferation of IEE cells in the occlusal region of molar tooth germs, resulting in the suppression of cusp formation. Our data thus suggest that BMP4 is involved in cusp formation and differentiation of ameloblasts in the occlusal region of molars.[1]

References

Bone morphogenetic protein 4 is involved in cusp formation in molar tooth germ of mice. Tabata, M.J., Fujii, T., Liu, J.G., Ohmori, T., Abe, M., Wakisaka, S., Iwamoto, M., Kurisu, K. Eur. J. Oral Sci. (2002) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.