The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Ameloblasts


High impact information on Ameloblasts


Biological context of Ameloblasts


Anatomical context of Ameloblasts


Associations of Ameloblasts with chemical compounds

  • To determine the efficiency of antisense treatment in this model system, digoxigenin-labeled oligodeoxynucleotides were observed to diffuse throughout the tooth explants including the target ameloblast cells within 24 hours [17].
  • Tetracycline was administered to rats in varying doses in order to study the likelihood of ultrastructural alterations to ameloblasts and to study odontoblasts and dentin as well [18].
  • The parent protein is a 186-kDa glycoprotein that concentrates along the secretory face of the ameloblast Tomes' process [19].
  • Maturing enamel overlaid by either ruffle-ended or smooth-ended maturation ameloblasts showed similar Ca and P concentrations [20].
  • The visualization of the patterns of ameloblast modulation by the glyoxal bis(2-hydroxyanil) staining method [21].

Gene context of Ameloblasts

  • The GMp motif in the N-terminal region of the cytokeratin 14 of ameloblasts binds to trityrosyl motif peptide (ATMP) of amelogenin (Ravindranath, R. M. H., Tam, W., Bringas, P., Santos, V., and Fincham, A. G. (2001) J. Biol. Chem. 276, 36586 - 36597) [22].
  • Amelogenin interacts with cytokeratin-5 in ameloblasts during enamel growth [22].
  • In early secretory ameloblasts, DSPP expression was transient and down-regulated with the appearance ofdentin matrix [23].
  • In situ hybridization studies showed expression of Dmp1 in odontoblasts with transient expression in secretory ameloblasts [24].
  • Quantitative analyses identified specific modulations of Dlx-2 expression in ameloblasts depending on the anatomical sites of the incisor, showing more specifically an inverse linear relationship between the Dlx-2 promoter activity level and enamel thickness [25].

Analytical, diagnostic and therapeutic context of Ameloblasts


  1. Mechanism of toxic action of fluoride in dental fluorosis: whether trimeric G proteins participate in the disturbance of intracellular transport of secretory ameloblast exposed to fluoride. Matsuo, S., Kiyomiya, K., Kurebe, M. Arch. Toxicol. (1998) [Pubmed]
  2. A histochemical study of the effects of high doses of sodium fluoride on dipeptidyl peptidase II activity in the rat incisor ameloblast. Smid, J.R., Monsour, P.A., Harbrow, D.J., Young, W.G. Arch. Oral Biol. (1990) [Pubmed]
  3. Transforming growth factor beta 2 in epithelial differentiation of developing teeth and odontogenic tumors. Heikinheimo, K., Happonen, R.P., Miettinen, P.J., Ritvos, O. J. Clin. Invest. (1993) [Pubmed]
  4. Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. Fukumoto, S., Kiba, T., Hall, B., Iehara, N., Nakamura, T., Longenecker, G., Krebsbach, P.H., Nanci, A., Kulkarni, A.B., Yamada, Y. J. Cell Biol. (2004) [Pubmed]
  5. Expression of Notch 1, 2 and 3 is regulated by epithelial-mesenchymal interactions and retinoic acid in the developing mouse tooth and associated with determination of ameloblast cell fate. Mitsiadis, T.A., Lardelli, M., Lendahl, U., Thesleff, I. J. Cell Biol. (1995) [Pubmed]
  6. Sonic hedgehog regulates growth and morphogenesis of the tooth. Dassule, H.R., Lewis, P., Bei, M., Maas, R., McMahon, A.P. Development (2000) [Pubmed]
  7. Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. D'Souza, R.N., Aberg, T., Gaikwad, J., Cavender, A., Owen, M., Karsenty, G., Thesleff, I. Development (1999) [Pubmed]
  8. Amelin: an enamel-related protein, transcribed in the cells of epithelial root sheath. Fong, C.D., Slaby, I., Hammarström, L. J. Bone Miner. Res. (1996) [Pubmed]
  9. Localization of EMSP1 expression during tooth formation and cloning of mouse cDNA. Hu, J.C., Ryu, O.H., Chen, J.J., Uchida, T., Wakida, K., Murakami, C., Jiang, H., Qian, Q., Zhang, C., Ottmers, V., Bartlett, J.D., Simmer, J.P. J. Dent. Res. (2000) [Pubmed]
  10. Laminin gamma2 expression is developmentally regulated during murine tooth morphogenesis and is intense in ameloblasts. Sahlberg, C., Hormia, M., Airenne, T., Thesleff, I. J. Dent. Res. (1998) [Pubmed]
  11. Alternative splicing of amelogenin mRNA from rat incisor ameloblasts. Li, R., Li, W., DenBesten, P.K. J. Dent. Res. (1995) [Pubmed]
  12. Expression patterns of the homeobox gene, Hox-8, in the mouse embryo suggest a role in specifying tooth initiation and shape. MacKenzie, A., Ferguson, M.W., Sharpe, P.T. Development (1992) [Pubmed]
  13. Cloning and characterization of rat dentin matrix protein 1 (DMP1) gene and its 5'-upstream region. Thotakura, S.R., Karthikeyan, N., Smith, T., Liu, K., George, A. J. Biol. Chem. (2000) [Pubmed]
  14. E- and N-cadherin distribution in developing and functional human teeth under normal and pathological conditions. Heymann, R., About, I., Lendahl, U., Franquin, J.C., Obrink, B., Mitsiadis, T.A. Am. J. Pathol. (2002) [Pubmed]
  15. Fluoride induces endoplasmic reticulum stress in ameloblasts responsible for dental enamel formation. Kubota, K., Lee, D.H., Tsuchiya, M., Young, C.S., Everett, E.T., Martinez-Mier, E.A., Snead, M.L., Nguyen, L., Urano, F., Bartlett, J.D. J. Biol. Chem. (2005) [Pubmed]
  16. A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts. Paine, C.T., Paine, M.L., Luo, W., Okamoto, C.T., Lyngstadaas, S.P., Snead, M.L. J. Biol. Chem. (2000) [Pubmed]
  17. Antisense inhibition of AMEL translation demonstrates supramolecular controls for enamel HAP crystal growth during embryonic mouse molar development. Diekwisch, T., David, S., Bringas, P., Santos, V., Slavkin, H.C. Development (1993) [Pubmed]
  18. Dose-dependent ultrastructural changes induced by tetracycline in developing dental tissues of the rat. Kruger, B.J. J. Dent. Res. (1975) [Pubmed]
  19. Cloning and characterization of porcine enamelin mRNAs. Hu, C.C., Fukae, M., Uchida, T., Qian, Q., Zhang, C.H., Ryu, O.H., Tanabe, T., Yamakoshi, Y., Murakami, C., Dohi, N., Shimizu, M., Simmer, J.P. J. Dent. Res. (1997) [Pubmed]
  20. Ameloblast modulation and changes in the Ca, P, and S content of developing enamel matrix as revealed by SEM-EDX. Sasaki, T., Debari, K., Garant, P.R. J. Dent. Res. (1987) [Pubmed]
  21. The visualization of the patterns of ameloblast modulation by the glyoxal bis(2-hydroxyanil) staining method. Takano, Y., Crenshaw, M.A., Bawden, J.W., Hammarström, L., Lindskog, S. J. Dent. Res. (1982) [Pubmed]
  22. Amelogenin interacts with cytokeratin-5 in ameloblasts during enamel growth. Ravindranath, R.M., Basilrose, R.M., Ravindranath, N.H., Vaitheesvaran, B. J. Biol. Chem. (2003) [Pubmed]
  23. Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo. D'Souza, R.N., Cavender, A., Sunavala, G., Alvarez, J., Ohshima, T., Kulkarni, A.B., MacDougall, M. J. Bone Miner. Res. (1997) [Pubmed]
  24. Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues. MacDougall, M., Gu, T.T., Luan, X., Simmons, D., Chen, J. J. Bone Miner. Res. (1998) [Pubmed]
  25. Biomineralization, life-time of odontogenic cells and differential expression of the two homeobox genes MSX-1 and DLX-2 in transgenic mice. Lézot, F., Thomas, B., Hotton, D., Forest, N., Orestes-Cardoso, S., Robert, B., Sharpe, P., Berdal, A. J. Bone Miner. Res. (2000) [Pubmed]
  26. Extracellular proteolysis alters tooth development in transgenic mice expressing urokinase-type plasminogen activator in the enamel organ. Zhou, H.M., Nichols, A., Wohlwend, A., Bolon, I., Vassalli, J.D. Development (1999) [Pubmed]
  27. Amelogenin gene expression in porcine odontoblasts. Oida, S., Nagano, T., Yamakoshi, Y., Ando, H., Yamada, M., Fukae, M. J. Dent. Res. (2002) [Pubmed]
  28. Identification of differentially expressed cDNA transcripts from a rat odontoblast cell line. Hao, J., He, G., Narayanan, K., Zou, B., Lin, L., Muni, T., Ramachandran, A., George, A. Bone (2005) [Pubmed]
  29. Localization of transcriptional co-activator CBP in the ameloblasts and the other enamel organ-derived cells of the rat incisor. Nishikawa, S. J. Histochem. Cytochem. (2002) [Pubmed]
WikiGenes - Universities