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Gene Review

Dmp1  -  dentin matrix protein 1

Mus musculus

Synonyms: AG1, AV020965, DMP-1, Dentin matrix acidic phosphoprotein 1, Dentin matrix protein 1, ...
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Disease relevance of Dmp1


High impact information on Dmp1

  • We disrupted sequences encoding the DNA-binding domain of DMP1 in mouse embryonic stem cells and derived animals lacking the functional protein [3].
  • The DMP1 transcription factor induces the ARF tumor suppressor gene in mouse fibroblasts, leading to cell cycle arrest in a p53-dependent manner [3].
  • RESULTS: A unique line of transgenic mice was created that overexpresses PP in the pancreatic islets with low levels of expression in other tissues including the brain [4].
  • The remaining PP transgenic mice gained less weight with specifically reduced food intake and fat mass compared with controls, a result that was more evident in male than in female mice [4].
  • Induction of p19(Arf) and p21(Cip1) by oncogenic Raf was compromised in Dmp1-null cells, which were resistant to Raf-mediated premature senescence [5].

Biological context of Dmp1

  • Taken together, these studies suggest that DMP-1 is essential for later dentinogenesis during postnatal development [6].
  • In vitro promoter studies were performed using plasmid constructs containing mouse DMP-1 and DSPP promoter sequences fused to the luciferase reporter gene [7].
  • Transient transfection studies demonstrate for the first time that TGF beta-1 downregulates both DMP-1 and DSPP genes [7].
  • Whereas no apparent abnormalities were observed in prenatal bone development, Dmp1-deficient (Dmp1(-/-)) mice unexpectedly develop a severe defect in cartilage formation during postnatal chondrogenesis [8].
  • To clarify these two issues, we have generated mice carrying a truncated Dmp1 gene by using gene targeting to replace exon 6 with a lacZ gene [9].

Anatomical context of Dmp1

  • In contrast to Dspp expression that was tooth-specific, Dmp1 was expressed by osteoblasts throughout ossification in the skeleton [10].
  • Reverse transcription-polymerase chain reaction was performed on embryonic day 13 to 1-day-old first molars using Dmp1- and DSPP-specific primer sets [10].
  • The dentin matrix protein-1 (DMP-1) gene is identified in odontoblasts during both embryonic and postnatal development [6].
  • Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development [6].
  • Dmp and Bsp mRNA was also expressed in the developing testis cords, supporting the view that all three SIBLING proteins may contribute to testis differentiation [11].

Associations of Dmp1 with chemical compounds


Enzymatic interactions of Dmp1


Regulatory relationships of Dmp1


Other interactions of Dmp1


Analytical, diagnostic and therapeutic context of Dmp1

  • In situ hybridization studies revealed a much broader Dmp1 tissue expression pattern than previously reported [19].
  • Studies of fetal rat calvarial (FRC) cell cultures showed that the expression of Dmp1 was associated closely with "bone nodule" formation and mineralization in vitro [20].
  • By immunocytochemistry using a C-terminal region peptide antibody to DMP1, we found that there was a transient decrease in immunoreactivity at 3 days after treatment on both the formation side and the resorption side compared with the matched contralateral control tissue [1].
  • In this study, we examined the effect of mechanical loading on expression of DMP1 mRNA and DMP1 protein in alveolar bone in the mouse tooth movement model by in situ hybridization and immunocytochemistry [1].
  • A DMP-1 DNA probe was generated1using PCR amplification of the mouse full-length DMP-1 and labeled with [32P] d-CTP [21].


  1. Mechanical loading stimulates dentin matrix protein 1 (DMP1) expression in osteocytes in vivo. Gluhak-Heinrich, J., Ye, L., Bonewald, L.F., Feng, J.Q., MacDougall, M., Harris, S.E., Pavlin, D. J. Bone Miner. Res. (2003) [Pubmed]
  2. DMP1 depletion decreases bone mineralization in vivo: an FTIR imaging analysis. Ling, Y., Rios, H.F., Myers, E.R., Lu, Y., Feng, J.Q., Boskey, A.L. J. Bone Miner. Res. (2005) [Pubmed]
  3. Disruption of the ARF transcriptional activator DMP1 facilitates cell immortalization, Ras transformation, and tumorigenesis. Inoue, K., Wen, R., Rehg, J.E., Adachi, M., Cleveland, J.L., Roussel, M.F., Sherr, C.J. Genes Dev. (2000) [Pubmed]
  4. Decreased food intake and body weight in pancreatic polypeptide-overexpressing mice. Ueno, N., Inui, A., Iwamoto, M., Kaga, T., Asakawa, A., Okita, M., Fujimiya, M., Nakajima, Y., Ohmoto, Y., Ohnaka, M., Nakaya, Y., Miyazaki, J.I., Kasuga, M. Gastroenterology (1999) [Pubmed]
  5. Ras-Raf-Arf signaling critically depends on the Dmp1 transcription factor. Sreeramaneni, R., Chaudhry, A., McMahon, M., Sherr, C.J., Inoue, K. Mol. Cell. Biol. (2005) [Pubmed]
  6. Deletion of dentin matrix protein-1 leads to a partial failure of maturation of predentin into dentin, hypomineralization, and expanded cavities of pulp and root canal during postnatal tooth development. Ye, L., MacDougall, M., Zhang, S., Xie, Y., Zhang, J., Li, Z., Lu, Y., Mishina, Y., Feng, J.Q. J. Biol. Chem. (2004) [Pubmed]
  7. TGF beta-1 downregulates DMP-1 and DSPP in odontoblasts. Unterbrink, A., O'Sullivan, M., Chen, S., MacDougall, M. Connect. Tissue Res. (2002) [Pubmed]
  8. Dmp1-deficient mice display severe defects in cartilage formation responsible for a chondrodysplasia-like phenotype. Ye, L., Mishina, Y., Chen, D., Huang, H., Dallas, S.L., Dallas, M.R., Sivakumar, P., Kunieda, T., Tsutsui, T.W., Boskey, A., Bonewald, L.F., Feng, J.Q. J. Biol. Chem. (2005) [Pubmed]
  9. The Dentin matrix protein 1 (Dmp1) is specifically expressed in mineralized, but not soft, tissues during development. Feng, J.Q., Huang, H., Lu, Y., Ye, L., Xie, Y., Tsutsui, T.W., Kunieda, T., Castranio, T., Scott, G., Bonewald, L.B., Mishina, Y. J. Dent. Res. (2003) [Pubmed]
  10. Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo. D'Souza, R.N., Cavender, A., Sunavala, G., Alvarez, J., Ohshima, T., Kulkarni, A.B., MacDougall, M. J. Bone Miner. Res. (1997) [Pubmed]
  11. Osteopontin and related SIBLING glycoprotein genes are expressed by Sertoli cells during mouse testis development. Wilson, M.J., Liaw, L., Koopman, P. Dev. Dyn. (2005) [Pubmed]
  12. In situ localization and chromosomal mapping of the AG1 (Dmp1) gene. George, A., Gui, J., Jenkins, N.A., Gilbert, D.J., Copeland, N.G., Veis, A. J. Histochem. Cytochem. (1994) [Pubmed]
  13. Dual functional roles of dentin matrix protein 1. Implications in biomineralization and gene transcription by activation of intracellular Ca2+ store. Narayanan, K., Ramachandran, A., Hao, J., He, G., Park, K.W., Cho, M., George, A. J. Biol. Chem. (2003) [Pubmed]
  14. Extracellular matrix proteins and the dynamics of dentin formation. Butler, W.T., Brunn, J.C., Qin, C., McKee, M.D. Connect. Tissue Res. (2002) [Pubmed]
  15. Expression of dentin matrix protein 1 (DMP1) in nonmineralized tissues. Terasawa, M., Shimokawa, R., Terashima, T., Ohya, K., Takagi, Y., Shimokawa, H. J. Bone Miner. Metab. (2004) [Pubmed]
  16. Expression of dentin matrix protein 1 (DMP1) during fracture healing. Toyosawa, S., Kanatani, N., Shintani, S., Kobata, M., Yuki, M., Kishino, M., Ijuhin, N., Komori, T. Bone (2004) [Pubmed]
  17. Transcriptional regulation of dentin matrix protein 1 by JunB and p300 during osteoblast differentiation. Narayanan, K., Srinivas, R., Peterson, M.C., Ramachandran, A., Hao, J., Thimmapaya, B., Scherer, P.E., George, A. J. Biol. Chem. (2004) [Pubmed]
  18. Transcriptional regulation of dentin matrix protein 1 (DMP1) by AP-1 (c-fos/c-jun) factors. Narayanan, K., Ramachandran, A., Hao, J., George, A. Connect. Tissue Res. (2002) [Pubmed]
  19. Identification of a novel isoform of mouse dentin matrix protein 1: spatial expression in mineralized tissues. MacDougall, M., Gu, T.T., Luan, X., Simmons, D., Chen, J. J. Bone Miner. Res. (1998) [Pubmed]
  20. Dentin matrix protein 1, a target molecule for Cbfa1 in bone, is a unique bone marker gene. Fen, J.Q., Zhang, J., Dallas, S.L., Lu, Y., Chen, S., Tan, X., Owen, M., Harris, S.E., MacDougall, M. J. Bone Miner. Res. (2002) [Pubmed]
  21. Dentin matrix protein-1, a candidate gene for dentinogenesis imperfecta. MacDougall, M., Gu, T.T., Simmons, D. Connect. Tissue Res. (1996) [Pubmed]
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