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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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HCV-specific cytokine induction in monocytes of patients with different outcomes of hepatitis C.

AIM: Cytokine release by macrophages critically determines the type of immune response to an antigen. Therefore, we studied hepatitis C virus (HCV)-specific induction of interleukins-1 beta, -10, -12 (IL-1 beta, IL-10, IL-12), and tumor necrosis factor-alpha (TNF-alpha) in monocytes. METHODS: Intracellular cytokine expression was studied by flow cytometry in 23 patients with chronic hepatitis C, 14 anti-HCV seropositives without viremia and 11 controls after stimulation of peripheral blood mononuclear cells with recombinant core, NS3, NS4, NS5a and NS5b proteins. RESULTS: Patients with HCV viremia revealed greater spontaneous expression of IL-1beta, TNF-alpha, and IL-10. Furthermore, greater than twofold higher IL-10 expression was induced by the HCV antigens in chronic hepatitis C than in the other two groups (P<0.05). In contrast, neither IL-12 nor TNF-alpha was induced preferentially. CONCLUSION: In chronic hepatitis C antigen-specific cytokine induction in monocytes is apparently shifted towards predominant IL-10 induction - not counterbalanced by antiviral type 1 cytokines. This may contribute to persistent viral replication.[1]

References

  1. HCV-specific cytokine induction in monocytes of patients with different outcomes of hepatitis C. Woitas, R.P., Petersen, U., Moshage, D., Brackmann, H.H., Matz, B., Sauerbruch, T., Spengler, U. World J. Gastroenterol. (2002) [Pubmed]
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