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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The human ASCL2 gene escaping genomic imprinting and its expression pattern.

The mouse achaete-scute homolog-2 gene ( Ascl2 or Mash2) encodes a transcription factor playing a role in the development of the trophoblast. The Ascl2 is an imprinted gene with maternal expression and assigned to an imprinting gene cluster region (ICR) at a distal region of mouse chromosome 7. We previously isolated a phage clone carrying the human homolog, ASCL2, and mapped it to human chromosome 11p15.5, a human ICR. In the present study, we demonstrate the expression patterns of the human ASCL2 in the fetus at a stage between first and second trimesters and in the placental tissues. In addition, it has been shown that the human ASCL2 gene escapes genomic imprinting.[1]

References

  1. The human ASCL2 gene escaping genomic imprinting and its expression pattern. Miyamoto, T., Hasuike, S., Jinno, Y., Soejima, H., Yun, K., Miura, K., Ishikawa, M., Niikawa, N. J. Assist. Reprod. Genet. (2002) [Pubmed]
 
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