The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

About

Terms

 

 
 
 
 

Inhibition of NF-kappaB activation by merlin.

The neurofibromatosis type 2 (NF2) gene encodes an ezrin-radixin-moesin (ERM) related protein, referred to as either merlin or schwannomin, that is known to be a tumor suppressor. NF-kappaB signaling is known to be important for controlling cellular proliferation and protecting against apoptosis. In this report, merlin was demonstrated to be effective in suppressing the NF-kappaB signaling pathway in NIH3T3 and C6 cells. In addition, merlin blocked the tumor necrosis factor-alpha (TNF-alpha)- induced NF-kappaB-DNA binding mediated via the inhibition of degradation of IkappaBalpha and blocked the activation of NF-kappaB-dependent transcription. A reporter gene assay using deletion mutants of NF2 showed that the N-terminus (amino acids 1-130) of merlin may be important for its inhibition of NF-kappaB activation. These results show that merlin acts as a negative regulator of the NF-kappaB signaling pathway.[1]

References

  1. Inhibition of NF-kappaB activation by merlin. Kim, J.Y., Kim, H., Jeun, S.S., Rha, S.J., Kim, Y.H., Ko, Y.J., Won, J., Lee, K.H., Rha, H.K., Wang, Y.P. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities