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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Effect of tonsillectomy on serum concentrations of interleukins and TNF-alpha in patients with chronic tonsillitis.

We investigated serum interleukin (IL)-1beta, IL-4, IL-6, IL-8 and tumor necrosis factor (TNF)-alpha levels in 17 children aged 5-12 years (mean 7) with chronic tonsillitis before and after tonsillectomy. Cytokine concentrations were measured by enzyme-linked immunosorbent assay. IL-1beta and IL-6 levels were significantly higher than the control levels (p < 0.05) in preoperative serum samples. Other cytokine levels were within normal limits. After tonsillectomy, IL-1beta and IL-6 levels were significantly reduced (p < 0.05). It is suggested that IL-1beta and IL-6 may be mediators which have a role in chronic tonsillitis disease and that tonsillectomy has a significant effect on preoperative IL-1beta and IL-6 serum levels.[1]

References

  1. Effect of tonsillectomy on serum concentrations of interleukins and TNF-alpha in patients with chronic tonsillitis. Unal, M., Oztürk, C., Görür, K. ORL J. Otorhinolaryngol. Relat. Spec. (2002) [Pubmed]
 
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