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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Massberg, S. et al.

Massberg, Brand, Grüner, Page, Müller, Müller, Bergmeier, Richter, Lorenz, Konrad, Nieswandt, Gawaz,

A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation.

The contribution of platelets to the process of atherosclerosis remains unclear. Here, we show in vivo that platelets adhere to the vascular endothelium of the carotid artery in ApoE(-)(/)(-) mice before the development of manifest atherosclerotic lesions. Platelet-endothelial cell interaction involved both platelet glycoprotein (GP)Ibalpha and GPIIb-IIIa. Platelet adhesion to the endothelium coincides with inflammatory gene expression and preceded atherosclerotic plaque invasion by leukocytes. Prolonged blockade of platelet adhesion in ApoE(-)(/)(-) mice profoundly reduced leukocyte accumulation in the arterial intima and attenuated atherosclerotic lesion formation in the carotid artery bifurcation, the aortic sinus, and the coronary arteries. These findings establish the platelet as a major player in initiation of the atherogenetic process.[1]

References

A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation. Massberg, S., Brand, K., Grüner, S., Page, S., Müller, E., Müller, I., Bergmeier, W., Richter, T., Lorenz, M., Konrad, I., Nieswandt, B., Gawaz, M. J. Exp. Med. (2002) [Pubmed]

Annotations and hyperlinks in this abstract are from individual authors of WikiGenes or automatically generated by the WikiGenes Data Mining Engine. The abstract is from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg