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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia.

The n-hexane extract that has shown activity in the tracheospasmolytic bioassay was fractionated by solvent extraction and from the major active fraction two compounds were isolated and identified as viteosin-A and vitexicarpin. These compounds blocked spontaneous contraction of isolated male guinea pig trachea induced by histamine; however only vitexicarpin was active in a model using sensitized guinea pig trachea stimulated by ovalbumin up to minimum dose of 1.3 x 10(-5) M. The result suggests that vitexicarpin is able to block effects of histamine released from sensitized mast cells possibly by stabilizing the mast cells membrane function.[1]

References

  1. Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia. Alam, G., Wahyuono, S., Ganjar, I.G., Hakim, L., Timmerman, H., Verpoorte, R. Planta Med. (2002) [Pubmed]
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