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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Casticin     5-hydroxy-2-(3-hydroxy-4- methoxy-phenyl)-3...

Synonyms: Vitexicarpin, AC1NSSVS, CHEMBL452767, SureCN382354, CHEBI:69355, ...
 
 
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Disease relevance of Casticin

 

High impact information on Casticin

 

Biological context of Casticin

 

Anatomical context of Casticin

 

Associations of Casticin with other chemical compounds

  • We studied the mechanism of anti-tumor activity of the flavonoid Casticin, derived from Achillea millefolium [5].
  • Interaction between the flavones casticin and artemetin and the antimalarial activity of chloroquine and qinghaosu (QHS) was examined using an in vitro growth assay based on [3H]hypoxanthine incorporation in synchronized cultures of a cloned line of Plasmodium falciparum [7].
 

Gene context of Casticin

References

  1. Vitexicarpin, a flavonoid from the fruits of Vitex rotundifolia, inhibits mouse lymphocyte proliferation and growth of cell lines in vitro. You, K.M., Son, K.H., Chang, H.W., Kang, S.S., Kim, H.P. Planta Med. (1998) [Pubmed]
  2. G2-M arrest and antimitotic activity mediated by casticin, a flavonoid isolated from Viticis Fructus (Vitex rotundifolia Linne fil.). Kobayakawa, J., Sato-Nishimori, F., Moriyasu, M., Matsukawa, Y. Cancer Lett. (2004) [Pubmed]
  3. New diterpenes and norditerpenes from the fruits of Vitex rotundifolia. Ono, M., Yanaka, T., Yamamoto, M., Ito, Y., Nohara, T. J. Nat. Prod. (2002) [Pubmed]
  4. Tracheospasmolytic activity of viteosin-A and vitexicarpin isolated from vitex trifolia. Alam, G., Wahyuono, S., Ganjar, I.G., Hakim, L., Timmerman, H., Verpoorte, R. Planta Med. (2002) [Pubmed]
  5. The flavonoid Casticin has multiple mechanisms of tumor cytotoxicity action. Ha??dara, K., Zamir, L., Shi, Q.W., Batist, G. Cancer Lett. (2006) [Pubmed]
  6. Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents. Hajdú, Z., Hohmann, J., Forgo, P., Martinek, T., Dervarics, M., Zupkó, I., Falkay, G., Cossuta, D., Máthé, I. Phytotherapy research : PTR (2007) [Pubmed]
  7. Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. Elford, B.C., Roberts, M.F., Phillipson, J.D., Wilson, R.J. Trans. R. Soc. Trop. Med. Hyg. (1987) [Pubmed]
 
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