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Nakatani, T. et al.

Nakatani, Tsuchida, Fu, Sugimura, Takemoto,

Effects of direct hemoperfusion with a beta2-microglobulin adsorption column on hypercytokinemia in rats.

BACKGROUND/AIM: Blood purification therapies have been clinically applied to treat the cytokine-induced pathological responses. The effects of direct hemoperfusion(DHP) with a beta(2)-microglobulin (BMG) adsorption column on hypercytokinemia were investigated. METHODS: A hypercytokinemia model was prepared by injecting lipopolysaccharide (LPS) into femoral veins of male Wistar rats weighing 250-400 g. The hypercytokinemic rats were connected to the DHP system using a small BMG adsorption column, and time course changes in plasma levels of inflammatory cytokines were then examined. RESULTS: Plasma levels of interleukins (IL) 1beta and 6 and tumor necrosis factor alpha (TNF-alpha) were found to be significantly elevated within 3 h after LPS injection in the control group that underwent extracorporeal circulation without the BMG adsorption column, whereas the increases in plasma levels of IL-6 and TNF-alpha were significantly inhibited in the group that was treated with the BMG adsorption column. The adsorption rates of cytokines with the BMG adsorption column were 20-40% for IL-1beta and IL-6 and 10-85% for TNF-alpha during treatment for 3 h. CONCLUSIONS: These results suggest that the systemic inflammatory response syndrome with hypercytokinemia might be treated with DHP using the BMG adsorption column.[1]

References

Effects of direct hemoperfusion with a beta2-microglobulin adsorption column on hypercytokinemia in rats. Nakatani, T., Tsuchida, K., Fu, O., Sugimura, K., Takemoto, Y. Blood Purif. (2003) [Pubmed]

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