The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

B2m  -  beta-2 microglobulin

Rattus norvegicus

Synonyms: Beta-2-microglobulin
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of B2m

  • Above a threshold of 100 mg/24 h, albuminuria induced by puromycin aminonucleoside (50 mg/kg) and Adriamycin (5 mg/kg) was associated with a marked increase in the urinary excretion of beta 2-microglobulin and cystatin C peaking at more than 100-fold the baseline levels [1].
  • Furthermore, immune precipitates formed from soluble tumour extracts containing hepatoma D23 specific antigen with turkey anti-rat beta 2 microglobulin failed to generate a tumour-specific antibody response in syngeneic rats althouth a cross-reactive antiserum was produced following immunization of allogeneic rats with the immune precipitate [2].
  • HLA-B27/beta2 microglobulin transgenic (TG) rats spontaneously develop T-cell-mediated colitis when colonized with normal commensal bacteria, but remain disease-free under germ-free conditions [3].
  • At the end of the study, only the interaction with beta 2-microglobulin excretion was still evident; that with the urinary excretion of beta-N-acetylglucosaminidase and albumin having been masked by the chronic progressive nephrosis affecting most animals at that stage [4].
  • These structures, antigenically related to AgB antigens, were not detected on plasmacytoma or hepatoma cells, nor did they display any antigenic similarity with rat beta 2-microglobulin [5].

High impact information on B2m


Chemical compound and disease context of B2m


Biological context of B2m


Anatomical context of B2m


Associations of B2m with chemical compounds


Physical interactions of B2m


Other interactions of B2m


Analytical, diagnostic and therapeutic context of B2m


  1. Competition between albumin and low-molecular-weight proteins for renal tubular uptake in experimental nephropathies. Thielemans, N., Lauwerys, R., Bernard, A. Nephron (1994) [Pubmed]
  2. Tumour antigens and alloantigens. II. Lack of association of rat hepatoma-D23-specific antigen with beta 2 microglobulin. Bowen, J.G., Baldwin, R.W. Int. J. Cancer (1979) [Pubmed]
  3. Dysregulated luminal bacterial antigen-specific T-cell responses and antigen-presenting cell function in HLA-B27 transgenic rats with chronic colitis. Qian, B.F., Tonkonogy, S.L., Hoentjen, F., Dieleman, L.A., Sartor, R.B. Immunology (2005) [Pubmed]
  4. Potentiation of cadmium nephrotoxicity by acetaminophen. Bernard, A.M., de Russis, R., Amor, A.O., Lauwerys, R.R. Arch. Toxicol. (1988) [Pubmed]
  5. Properties of purified papain-solubilized rat AgB antigens and reactivity of a xenoantiserum against the isolated antigens. Kvist, S., Eriksson, U., Peterson, P.A. Scand. J. Immunol. (1980) [Pubmed]
  6. An Fc receptor structurally related to MHC class I antigens. Simister, N.E., Mostov, K.E. Nature (1989) [Pubmed]
  7. A major histocompatibility complex class I-related Fc receptor for IgG on rat hepatocytes. Blumberg, R.S., Koss, T., Story, C.M., Barisani, D., Polischuk, J., Lipin, A., Pablo, L., Green, R., Simister, N.E. J. Clin. Invest. (1995) [Pubmed]
  8. Beta 2-microglobulin enhances insulin-like growth factor I receptor levels and synthesis in bone cell cultures. Centrella, M., McCarthy, T.L., Canalis, E. J. Biol. Chem. (1989) [Pubmed]
  9. Isolation, purification, and amino acid composition of the tunicate hemocyte Thy-1 homolog. Mansour, M.H., DeLange, R., Cooper, E.L. J. Biol. Chem. (1985) [Pubmed]
  10. Effect of oxoplatinum and CBDCA on renal functions in rats. Láznícková, A., Semecký, V., Láznícek, M., Zubr, V., Koksál, J., Kvĕtina, J. Neoplasma (1989) [Pubmed]
  11. Nucleotide sequence of rat beta 2-microglobulin cDNA. Mauxion, F., Kress, M. Nucleic Acids Res. (1987) [Pubmed]
  12. The cDNA structure and expression analysis of the genes for the cysteine proteinase inhibitor cystatin C and for beta 2-microglobulin in rat brain. Cole, T., Dickson, P.W., Esnard, F., Averill, S., Risbridger, G.P., Gauthier, F., Schreiber, G. Eur. J. Biochem. (1989) [Pubmed]
  13. The class I major histocompatibility complex related Fc receptor shows pH-dependent stability differences correlating with immunoglobulin binding and release. Raghavan, M., Gastinel, L.N., Bjorkman, P.J. Biochemistry (1993) [Pubmed]
  14. Beta 2-microglobulin co-distributes with the heavy chain of the intestinal IgG-Fc receptor throughout the transepithelial transport pathway of the neonatal rat. Berryman, M., Rodewald, R. J. Cell. Sci. (1995) [Pubmed]
  15. Overproduction and secretion of beta 2-microglobulin by a rat thymic epithelial cell line that expresses MHC class I heavy chain. Dargemont, C., Dunon, D., Salamero, J., Deugnier, M.A., Davoust, J., Thiery, J.P. J. Cell. Sci. (1991) [Pubmed]
  16. Dietary vitamin E supplementation ameliorates renal injury in chronic puromycin aminonucleoside nephropathy. Trachtman, H., Schwob, N., Maesaka, J., Valderrama, E. J. Am. Soc. Nephrol. (1995) [Pubmed]
  17. Bleomycin regulation of transforming growth factor-beta mRNA in rat lung fibroblasts. Breen, E., Shull, S., Burne, S., Absher, M., Kelley, J., Phan, S., Cutroneo, K.R. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  18. Interaction between laminin, fibronectin and the light chain of the H2 complex. Attachment of glomerular cells to basement membranes by linking the endoskeleton to the exoskeleton by a transmembrane protein. Lubec, G. Renal physiology. (1986) [Pubmed]
  19. MHC class I, beta2 microglobulin, and the INF-gamma receptor are upregulated in aged motoneurons. Edström, E., Kullberg, S., Ming, Y., Zheng, H., Ulfhake, B. J. Neurosci. Res. (2004) [Pubmed]
  20. Size-selectivity of the glomerular barrier to high molecular weight proteins: upper size limitations of shunt pathways. Tencer, J., Frick, I.M., Oquist, B.W., Alm, P., Rippe, B. Kidney Int. (1998) [Pubmed]
  21. Bulk purification of a naturally occurring soluble form of RT1-A class I major histocompatibility complex antigens from DA rat liver, and studies of specific immunosuppression. Spencer, S.C., Fabre, J.W. Transplantation (1987) [Pubmed]
  22. mRNA encoding the beta-subunit of the mitochondrial F1-ATPase complex is a localized mRNA in rat hepatocytes. Egea, G., Izquierdo, J.M., Ricart, J., San Martín, C., Cuezva, J.M. Biochem. J. (1997) [Pubmed]
  23. Prolonged survival of heart allografts in rats treated with antisera to beta2-microglobulin. Bjorck, L., Konrad, P., Husberg, B., Berggard, I. Transplantation (1977) [Pubmed]
  24. Expression of MHC class I and beta2-microglobulin in rat spinal motoneurons: regulatory influences by IFN-gamma and axotomy. Lindå, H., Hammarberg, H., Cullheim, S., Levinovitz, A., Khademi, M., Olsson, T. Exp. Neurol. (1998) [Pubmed]
  25. Effects of direct hemoperfusion with a beta2-microglobulin adsorption column on hypercytokinemia in rats. Nakatani, T., Tsuchida, K., Fu, O., Sugimura, K., Takemoto, Y. Blood Purif. (2003) [Pubmed]
  26. Appearance of beta-2-microglobulin in rat hypothalamic magnocellular neurons after hypophysectomy. Shinoda, M., Ohe, Y., Katakai, K., Kabeya, K., Watanabe, M., Miura, T., Ishikawa, K. Neuroendocrinology (1996) [Pubmed]
WikiGenes - Universities