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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Lip hypertrophy secondary to cyclosporin treatment.

Gingival hypertrophy is a well-documented side effect of cyclosporin therapy, but severe lip enlargement is less frequently recognised. This can lead to poor body image, low self-esteem and non-compliance, especially in the older childhood and adolescent age groups. We describe two paediatric renal transplant recipients who had marked lip hypertrophy as a consequence of cyclosporin (Neoral) treatment. On changing the immunosuppression to tacrolimus (Prograf), this resolved. We recommend that a change in immunosuppressant therapy be considered in children with significant changes to facial appearance.[1]


  1. Lip hypertrophy secondary to cyclosporin treatment. Cansick, J.C., Hulton, S.A. Pediatr. Nephrol. (2003) [Pubmed]
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