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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Flagellin gene fliC of Xanthomonas campestris is upregulated by transcription factor Clp.

Clp, a homologue of cyclic AMP receptor protein (CRP), of Xanthomonas campestris regulates the expression of many genes. In this study, proteomic analysis showed the amounts of several extracellular proteins in a clp mutant to be reduced, including the flagellin encoded by fliC. Transcriptional fusion assay showed that activity of fliC promoter is reduced by 2.3-fold in clp mutant compared to the wild-type, coincident with the protein levels. The clp mutant is slightly reduced in motility; however, electron microscopy showed no significant change in the monotrichous flagellation. A fleQ homologue with conserved Clp-binding site in the upstream region is present in the fully sequenced X. campestris genome, suggesting that regulation of the flagellar genes is similar to that of Pseudomonas aeruginosa in involving Vfr, the CRP homologue, and FleQ in a cascade manner except that Vfr downregulates fleQ. Concomitant loss of flagellum and motility in fliC mutant and absence of a second homologue in the genome sequence suggest that X. campestris possesses a single flagellin gene, fliC. In addition, mutation of this gene does not affect virulence.[1]


  1. Flagellin gene fliC of Xanthomonas campestris is upregulated by transcription factor Clp. Lee, M.C., Weng, S.F., Tseng, Y.H. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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