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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The impact of ethanol and tobacco smoke on intranasal epithelium in the rat.

BACKGROUND: Investigations have shown the influence of ethanol and tobacco smoke on olfaction, epithelial metaplasia, and cancer formation in the head and neck. Analysis of ethanol and tobacco smoke-induced histopathological mucosal changes in the upper respiratory tract may provide important insight into the pathophysiology of secondary olfactory dysfunction. METHODS: Three groups of laboratory rats were experimentally exposed to either ethanol, tobacco smoke, or both, with a control group having no such exposure. RESULTS: Compared with controls, histopathological analysis of nasal mucosa in exposed rats revealed a decrease in the length of olfactory epithelium, especially in the rats exposed to both ethanol and tobacco smoke. Structural changes included loss of cilia and metaplasia. CONCLUSION: The histological changes noted in rats after ethanol and tobacco smoke exposure, if relevant to human physiology, could explain the decreased olfactory ability seen in patients who use these products.[1]


  1. The impact of ethanol and tobacco smoke on intranasal epithelium in the rat. Vent, J., Bartels, S., Haynatzki, G., Gentry-Nielsen, M.J., Leopold, D.A., Hallworth, R. American journal of rhinology. (2003) [Pubmed]
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