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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Fat-body-specific expression of the Drosophila Lsp-2 gene.

The larval serum protein-2 gene (Lsp-2) of Drosophila melanogaster is expressed at a very high level in the fat body of third-instar larvae. Here we report that Lsp-2 transcription in adult flies produces a unique mRNA localized in the adult adipose tissue of the head in both sexes. To identify regulatory regions of this Drosophila gene, Lsp-2 5'-flanking DNA sequences were fused to the E. coli beta-galactosidase gene (lacZ). Transient expression of the hybrid gene in third-instar larvae indicates that 230 bp just upstream from the 'TATA box' of the Lsp-2 gene are sufficient for larval fat body-specific expression.[1]


  1. Fat-body-specific expression of the Drosophila Lsp-2 gene. Benes, H., Spivey, D.W., Miles, J., Neal, K., Edmondson, R.G. SAAS Bull. Biochem. Biotechnol. (1990) [Pubmed]
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