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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Intravascular insulin gene delivery as potential therapeutic intervention in diabetes mellitus.

We assessed therapeutic potential of intravascular insulin gene delivery in a diabetic murine model. The rat proinsulin-1 gene cDNA engineered to harbor furin consensus cleavage sequences was inserted into EBV-based plasmid vectors that contained CAG promoter or multimerized rat insulin promoter (RIP). Normal or streptozotocin (STZ)-induced diabetic mice were given an injection of the plasmids via the tail vein under high pressure. Transfection of the CAG-proinsulin construct markedly improved hyperglycemia of diabetic mice, accompanied by a considerable increase in serum insulin concentrations. Although the RIP-plasmid failed to reduce fasting blood glucose, the glucose tolerance test and RT-PCR analysis revealed that insulin production was regulated in the liver in a blood glucose level-dependent manner. The present results suggest a potential therapeutic means of controlling DM.[1]


  1. Intravascular insulin gene delivery as potential therapeutic intervention in diabetes mellitus. Yasutomi, K., Itokawa, Y., Asada, H., Kishida, T., Cui, F.D., Ohashi, S., Gojo, S., Ueda, Y., Kubo, T., Yamagishi, H., Imanishi, J., Takeuchi, T., Mazda, O. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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