Gene Review:
Furin - furin (paired basic amino acid cleaving...
Mus musculus
Synonyms:
9130404I01Rik, Dibasic-processing enzyme, Fur, PACE, Paired basic amino acid residue-cleaving enzyme, ...
Thomas,
Roebroek,
Umans,
Pauli,
Robertson,
van Leuven,
Van de Ven,
Constam,
de Kleijn,
Sluijter,
Smit,
Velema,
Richard,
Schoneveld,
Pasterkamp,
Borst,
- The crystal structure of the proprotein processing proteinase furin explains its stringent specificity. Henrich, S., Cameron, A., Bourenkov, G.P., Kiefersauer, R., Huber, R., Lindberg, I., Bode, W., Than, M.E. Nat. Struct. Biol. (2003)
- Furin-mediated cleavage of Pseudomonas exotoxin-derived chimeric toxins. Chiron, M.F., Fryling, C.M., FitzGerald, D. J. Biol. Chem. (1997)
- Furin is important but not essential for the proteolytic maturation of gp160 of HIV-1. Gu, M., Rappaport, J., Leppla, S.H. FEBS Lett. (1995)
- Resuscitating mutations in a furin cleavage-deficient mutant of the flavivirus tick-borne encephalitis virus. Elshuber, S., Mandl, C.W. J. Virol. (2005)
- Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Kim, S.H., Wang, R., Gordon, D.J., Bass, J., Steiner, D.F., Lynn, D.G., Thinakaran, G., Meredith, S.C., Sisodia, S.S. Nat. Neurosci. (1999)
- Furin at the cutting edge: from protein traffic to embryogenesis and disease. Thomas, G. Nat. Rev. Mol. Cell Biol. (2002)
- SPC4/PACE4 regulates a TGFbeta signaling network during axis formation. Constam, D.B., Robertson, E.J. Genes Dev. (2000)
- Major histocompatibility complex class I viral antigen processing in the secretory pathway defined by the trans-Golgi network protease furin. Gil-Torregrosa, B.C., Raúl Castaño, A., Del Val, M. J. Exp. Med. (1998)
- Proteolytic processing activates a viral superantigen. Mix, D., Winslow, G.M. J. Exp. Med. (1996)
- Polyarginine inhibits gp160 processing by furin and suppresses productive human immunodeficiency virus type 1 infection. Kibler, K.V., Miyazato, A., Yedavalli, V.S., Dayton, A.I., Jacobs, B.L., Dapolito, G., Kim, S.J., Jeang, K.T. J. Biol. Chem. (2004)
- The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen. Kehres, D.G., Zaharik, M.L., Finlay, B.B., Maguire, M.E. Mol. Microbiol. (2000)
- The amino-terminal residue of Sindbis virus glycoprotein E2 influences virus maturation, specific infectivity for BHK cells, and virulence in mice. Heidner, H.W., Johnston, R.E. J. Virol. (1994)
- Inter-alpha-inhibitor proteins are endogenous furin inhibitors and provide protection against experimental anthrax intoxication. Opal, S.M., Artenstein, A.W., Cristofaro, P.A., Jhung, J.W., Palardy, J.E., Parejo, N.A., Lim, Y.P. Infect. Immun. (2005)
- Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine. Komiyama, T., Swanson, J.A., Fuller, R.S. Antimicrob. Agents Chemother. (2005)
- Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. Roebroek, A.J., Umans, L., Pauli, I.G., Robertson, E.J., van Leuven, F., Van de Ven, W.J., Constam, D.B. Development (1998)
- Defective processing of the insulin receptor in an endoprotease-deficient Chinese hamster cell strain is corrected by expression of mouse furin. Robertson, B.J., Moehring, J.M., Moehring, T.J. J. Biol. Chem. (1993)
- Chromosomal assignments of the genes for neuroendocrine convertase PC1 (NEC1) to human 5q15-21, neuroendocrine convertase PC2 (NEC2) to human 20p11.1-11.2, and furin (mouse 7[D1-E2] region). Seidah, N.G., Mattei, M.G., Gaspar, L., Benjannet, S., Mbikay, M., Chrétien, M. Genomics (1991)
- The family of subtilisin/kexin like pro-protein and pro-hormone convertases: divergent or shared functions. Seidah, N.G., Chrétien, M., Day, R. Biochimie (1994)
- Human prohormone convertase 3 gene: exon-intron organization and molecular scanning for mutations in Japanese subjects with NIDDM. Ohagi, S., Sakaguchi, H., Sanke, T., Tatsuta, H., Hanabusa, T., Nanjo, K. Diabetes (1996)
- Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway. Liu, G., Thomas, L., Warren, R.A., Enns, C.A., Cunningham, C.C., Hartwig, J.H., Thomas, G. J. Cell Biol. (1997)
- Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment. Guzman-Ayala, M., Ben-Haim, N., Beck, S., Constam, D.B. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping. Constam, D.B., Robertson, E.J. Development (2000)
- Proprotein-processing endoprotease furin decreases regulated secretory pathway-specific proteins in the pancreatic beta cell line MIN6. Kayo, T., Sawada, Y., Suzuki, Y., Suda, M., Tanaka, S., Konda, Y., Miyazaki, J., Takeuchi, T. J. Biol. Chem. (1996)
- Heterologous processing of prosomatostatin in constitutive and regulated secretory pathways. Putative role of the endoproteases furin, PC1, and PC2. Galanopoulou, A.S., Kent, G., Rabbani, S.N., Seidah, N.G., Patel, Y.C. J. Biol. Chem. (1993)
- Kainic acid increases the expression of the prohormone convertases furin and PC1 in the mouse hippocampus. Meyer, A., Chrétien, P., Massicotte, G., Sargent, C., Chrétien, M., Marcinkiewicz, M. Brain Res. (1996)
- Kex2 family endoprotease furin is expressed specifically in pit-region parietal cells of the rat gastric mucosa. Kamimura, H., Konda, Y., Yokota, H., Takenoshita, S., Nagamachi, Y., Kuwano, H., Takeuchi, T. Am. J. Physiol. (1999)
- Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway. Hosaka, M., Nagahama, M., Kim, W.S., Watanabe, T., Hatsuzawa, K., Ikemizu, J., Murakami, K., Nakayama, K. J. Biol. Chem. (1991)
- Furin and membrane type-1 metalloproteinase mRNA levels and activation of metalloproteinase-2 are associated with arterial remodeling. de Kleijn, D.P., Sluijter, J.P., Smit, J., Velema, E., Richard, W., Schoneveld, A.H., Pasterkamp, G., Borst, C. FEBS Lett. (2001)
- Furin and prohormone convertase 1/3 are major convertases in the processing of mouse pro-growth hormone-releasing hormone. Dey, A., Norrbom, C., Zhu, X., Stein, J., Zhang, C., Ueda, K., Steiner, D.F. Endocrinology (2004)
- Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Seidah, N.G., Marcinkiewicz, M., Benjannet, S., Gaspar, L., Beaubien, G., Mattei, M.G., Lazure, C., Mbikay, M., Chrétien, M. Mol. Endocrinol. (1991)
- Localization of Kex2-like processing endoproteases, furin and PC4, within mouse testis by in situ hybridization. Torii, S., Yamagishi, T., Murakami, K., Nakayama, K. FEBS Lett. (1993)
- Prohormone convertases in mouse submandibular gland: co-localization of furin and nerve growth factor. Farhadi, H., Pareek, S., Day, R., Dong, W., Chrétien, M., Bergeron, J.J., Seidah, N.G., Murphy, R.A. J. Histochem. Cytochem. (1997)
- Identification and functional expression of a new member of the mammalian Kex2-like processing endoprotease family: its striking structural similarity to PACE4. Nakagawa, T., Hosaka, M., Torii, S., Watanabe, T., Murakami, K., Nakayama, K. J. Biochem. (1993)
- Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1. Marschang, P., Brich, J., Weeber, E.J., Sweatt, J.D., Shelton, J.M., Richardson, J.A., Hammer, R.E., Herz, J. Mol. Cell. Biol. (2004)
- Tissue distribution and processing of proSAAS by proprotein convertases. Sayah, M., Fortenberry, Y., Cameron, A., Lindberg, I. J. Neurochem. (2001)