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Quiles, J.L. et al.

Quiles, Farquharson, Ramírez-Tortosa, Grant, Milne, Huertas, Battino, Mataix, Wahle,

Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells.

The aim of this study was to investigate the role of coenzyme Q on the mRNA abundance of PHGPx and the reactive oxygen species (ROS) production in two different cell lines from human prostate, a line of non cancer cells (PNT2) and a line of cancer cells ( PC3). Results showed that malignant cells markedly differ in their response to coenzyme Q compared to non-malignant cells, with no changes in PHGPx expression and greater ROS production. Furthermore coenzyme Q supplementation significantly lowered cell growth of the PC3 cancer line without affecting the PNT2. If these results are confirmed with additional experiments, it could represent a novel and interesting approach on the biomedical use of coenzyme Q10 in cancer therapy.[1]

References

Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells. Quiles, J.L., Farquharson, A.J., Ramírez-Tortosa, M.C., Grant, I., Milne, L., Huertas, J.R., Battino, M., Mataix, J., Wahle, K.W. Biofactors (2003) [Pubmed]

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